CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)

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Accession:157157
This NEURON code implements a microcircuit of CA1 pyramidal neuron and consists of a detailed model of CA1 pyramidal cell and four types of inhibitory interneurons (basket, bistratified, axoaxonic and oriens lacunosum-moleculare cells). Synaptic plasticity during theta cycles at a synapse in a single spine on the stratum radiatum dendrite of the CA1 pyramidal cell is modeled using a phenomenological model of synaptic plasticity (Graupner and Brunel, PNAS 109(20):3991-3996, 2012). The code is adapted from the Poirazi CA1 pyramidal cell (ModelDB accession number 20212) and the Cutsuridis microcircuit model (ModelDB accession number 123815)
Reference:
1 . Saudargiene A, Cobb S, Graham BP (2015) A computational study on plasticity during theta cycles at Schaffer collateral synapses on CA1 pyramidal cells in the hippocampus. Hippocampus 25:208-18 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell; Hippocampus CA1 basket cell; Hippocampus CA1 bistratified cell; Hippocampus CA1 axo-axonic cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Long-term Synaptic Plasticity; STDP;
Implementer(s): Saudargiene, Ausra [ausra.saudargiene at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell;
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SaudargieneEtAl2015
readme.html
ANsyn.mod *
bgka.mod *
bistableGB_DOWNUP.mod
burststim2.mod *
cad.mod
cadiffus.mod *
cagk.mod *
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h.mod
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kadbru.mod
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kapbru.mod
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Kaxon.mod *
kca.mod *
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km.mod *
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LcaMig.mod *
my_exp2syn.mod *
Naaxon.mod *
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nap.mod
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nca.mod *
nmda.mod *
nmdaca.mod *
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somacar.mod *
STDPE2Syn.mod *
apical-non-trunk-list.hoc
apical-tip-list.hoc
apical-tip-list-addendum.hoc
apical-trunk-list.hoc
axoaxonic_cell17S.hoc
axon-sec-list.hoc
BasalPath.hoc
basal-paths.hoc
basal-tree-list.hoc
basket_cell17S.hoc
bistratified_cell13S.hoc
burst_cell.hoc
current-balance.hoc *
main.hoc
map-segments-to-3d.hoc *
mod_func.c
mosinit.hoc
ObliquePath.hoc *
oblique-paths.hoc
olm_cell2.hoc
pattsN100S20P5_single.dat
PC.ses
peri-trunk-list.hoc
pyramidalNeuron.hoc
randomLocation.hoc
ranstream.hoc
screenshot.png
soma-list.hoc
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vector-distance.hoc
                            
TITLE K-A channel from Klee Ficker and Heinemann
: modified by Brannon and Yiota Poirazi (poirazi@LNC.usc.edu)
: to account for Hoffman et al 1997 proximal region kinetics
: used only in soma and sections located < 100 microns from the soma

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)

}

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

PARAMETER {                       :parameters that can be entered when function is called in cell-setup
        dt              (ms)
	v               (mV)
        ek = -77        (mV)      :K reversal potential  (reset in cell-setup.hoc)
	celsius = 24	(degC)
       	gkabar = 0      (mho/cm2) :initialized conductance
        vhalfn = 11     (mV)      :activation half-potential
        vhalfl = -56    (mV) 	  :inactivation half-potential
        a0n = 0.05      (/ms)     :parameters used
        zetan = -1.5    (1)       :in calculation of
        zetal = 3       (1)       :steady state values
        gmn = 0.55      (1)       :and time constants
        gml = 1         (1)
	lmin = 2        (mS)
	nmin = 0.1      (mS)
	pw = -1         (1)
	tq = -40
	qq = 5
	q10 = 5                   :temperature sensitivity
}


NEURON {
	SUFFIX kap
	USEION k READ ek WRITE ik
        RANGE gkabar,gka
        GLOBAL ninf,linf,taul,taun,lmin
}

STATE {          :the unknown parameters to be solved in the DEs 
	n l
}
 
ASSIGNED {       :parameters needed to solve DE
	ik (mA/cm2)
        ninf
        linf      
        taul
        taun
        gka
}

INITIAL {		:initialize the following parameter using rates()
	rates(v)
	n = ninf
	l = linf
	gka = gkabar*n*l
	ik = gka*(v-ek)
}

BREAKPOINT {
	SOLVE states 
	gka = gkabar*n*l
	ik = gka*(v-ek)
}


FUNCTION alpn(v(mV)) { LOCAL zeta 
  zeta = zetan+pw/(1+exp((v-tq)/qq))
  alpn = exp(1.e-3*zeta*(v-vhalfn)*9.648e4/(8.315*(273.16+celsius))) 
}

FUNCTION betn(v(mV)) { LOCAL zeta
  zeta = zetan+pw/(1+exp((v-tq)/qq))
  betn = exp(1.e-3*zeta*gmn*(v-vhalfn)*9.648e4/(8.315*(273.16+celsius))) 
}

FUNCTION alpl(v(mV)) {
  alpl = exp(1.e-3*zetal*(v-vhalfl)*9.648e4/(8.315*(273.16+celsius))) 
}

FUNCTION betl(v(mV)) {
  betl = exp(1.e-3*zetal*gml*(v-vhalfl)*9.648e4/(8.315*(273.16+celsius))) 
}

LOCAL facn,facl
:if state_borgka is called from hoc, garbage or segmentation violation will
:result because range variables won't have correct pointer.  This is because
: only BREAKPOINT sets up the correct pointers to range variables.
PROCEDURE states() {     : exact when v held constant; integrates over dt step
        rates(v)
        n = n + facn*(ninf - n)
        l = l + facl*(linf - l)
        VERBATIM
        return 0;
        ENDVERBATIM
}

PROCEDURE rates(v (mV)) {                  :callable from hoc
        LOCAL a,qt
        qt = q10^((celsius-24)/10)         : temprature adjastment factor
        a = alpn(v)
        ninf = 1/(1 + a)                   : activation variable steady state value
        taun = betn(v)/(qt*a0n*(1+a))      : activation variable time constant
	if (taun<nmin) {taun=nmin}         : time constant not allowed to be less than nmin
        facn = (1 - exp(-dt/taun))
        a = alpl(v)
        linf = 1/(1+ a)                    : inactivation variable steady state value
	taul = 0.26*(v+50)                 : inactivation variable time constant
	if (taul<lmin) {taul=lmin}         : time constant not allowed to be less than lmin
        facl = (1 - exp(-dt/taul))
}