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Firing neocortical layer V pyramidal neuron (Reetz et al. 2014; Stadler et al. 2014)
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Accession:
168148
Neocortical Layer V model with firing behaviour adjusted to in vitro observations. The model was used to investigate the effects of IFN and PKC on the excitability of neurons (Stadler et al 2014, Reetz et al. 2014). The model contains new channel simulations for HCN1, HCN2 and the big calcium dependent potassium channel BK.
Reference:
1 .
Stadler K, Bierwirth C, Stoenica L, Battefeld A, Reetz O, Mix E, Schuchmann S, Velmans T, Rosenberger K, Bräuer AU, Lehnardt S, Nitsch R, Budt M, Wolff T, Kole MH, Strauss U (2014) Elevation in type I interferons inhibits HCN1 and slows cortical neuronal oscillations.
Cereb Cortex
24
:199-210
[
PubMed
]
2 .
Reetz O, Stadler K, Strauss U (2014) Protein kinase C activation mediates interferon-ß-induced neuronal excitability changes in neocortical pyramidal neurons.
J Neuroinflammation
11
:185
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Neocortex;
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I A;
I K;
I M;
I h;
I K,Ca;
I Sodium;
I Calcium;
I Mixed;
I Potassium;
I Q;
Gap Junctions:
Receptor(s):
Gene(s):
HCN1;
HCN2;
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Activity Patterns;
Detailed Neuronal Models;
Action Potentials;
Signaling pathways;
Implementer(s):
Stadler, Konstantin [konstantin.stadler at ntnu.no];
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
I Na,p
;
I Na,t
;
I L high threshold
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I Sodium
;
I Calcium
;
I Mixed
;
I Potassium
;
I Q
;
/
stadler2014_layerV
geo
sub
readme.html
readme_alt_format.html
ca.mod
cad.mod
caT.mod
HCN1r.mod
HCN2r.mod
kadist.mod
kaprox.mod
kBK.mod
kca.mod
km.mod
kv.mod
*
Other models using kv.mod:
A model of optimal learning with redundant synaptic connections (Hiratani & Fukai 2018)
Altered complexity in layer 2/3 pyramidal neurons (Luuk van der Velden et al. 2012)
Cortical pyramidal neuron, phase response curve (Stiefel et al 2009)
Dendritic Discrimination of Temporal Input Sequences (Branco et al. 2010)
Engaging distinct oscillatory neocortical circuits (Vierling-Claassen et al. 2010)
Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007)
L5 pyr. cell spiking control by oscillatory inhibition in distal apical dendrites (Li et al 2013)
Stochastic Ih and Na-channels in pyramidal neuron dendrites (Kole et al 2006)
na.mod
*
Other models using na.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008)
Nap.mod
nax.mod
*
Other models using nax.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008)
syn.mod
*
Other models using syn.mod:
Dentate Basket Cell: spatial summation of inhibitory synaptic inputs (Bartos et al 2001)
Fast AMPA receptor signaling (Geiger et al 1997)
Stochastic Ih and Na-channels in pyramidal neuron dendrites (Kole et al 2006)
LayerVinit.hoc
LayerVrun.hoc
mosinit.hoc
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