Firing neocortical layer V pyramidal neuron (Reetz et al. 2014; Stadler et al. 2014)

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Accession:168148
Neocortical Layer V model with firing behaviour adjusted to in vitro observations. The model was used to investigate the effects of IFN and PKC on the excitability of neurons (Stadler et al 2014, Reetz et al. 2014). The model contains new channel simulations for HCN1, HCN2 and the big calcium dependent potassium channel BK.
Reference:
1 . Stadler K, Bierwirth C, Stoenica L, Battefeld A, Reetz O, Mix E, Schuchmann S, Velmans T, Rosenberger K, Bräuer AU, Lehnardt S, Nitsch R, Budt M, Wolff T, Kole MH, Strauss U (2014) Elevation in type I interferons inhibits HCN1 and slows cortical neuronal oscillations. Cereb Cortex 24:199-210 [PubMed]
2 . Reetz O, Stadler K, Strauss U (2014) Protein kinase C activation mediates interferon-ß-induced neuronal excitability changes in neocortical pyramidal neurons. J Neuroinflammation 11:185 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I A; I K; I M; I h; I K,Ca; I Sodium; I Calcium; I Mixed; I Potassium; I Q;
Gap Junctions:
Receptor(s):
Gene(s): HCN1; HCN2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Detailed Neuronal Models; Action Potentials; Signaling pathways;
Implementer(s): Stadler, Konstantin [konstantin.stadler at ntnu.no];
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic GLU cell; I Na,p; I Na,t; I L high threshold; I A; I K; I M; I h; I K,Ca; I Sodium; I Calcium; I Mixed; I Potassium; I Q;
//######################################
//  						    
//  LayerVrun.hoc		
//  -------------
//
// Main hoc to start the model
//  							
//  Author: Konstantin Stadler
//  Version: 20131108
//  							
//######################################
//
// Loads the morphology and ion channels distributions
//
// Morphology based on Ri18 from Stuart and Spruston 1998 (Ri18geo.hoc):
//      http://senselab.med.yale.edu/modeldb/showmodel.asp?model=3677
//      PMID: 9570781 
//      
// The naming of sections in Ri18 is somehow confusing...
// This routine summarises the sections into lists:
//
//  -  SectionList Axon: the axon
//  -  SectionList SomaDend: everything except the axon
//  -  SectionList Soma: the Soma
//  -  SectionList ApikalDend: apical dendrite
//  -  Array ApikalTrunk: trunk part of the apical dendrite
//
// *Default accessed section*: dend1[21]
//      That's the middle of the soma  
//
// ************************************************************************** //
// ************************************************************************** //

load_file("nrngui.hoc")

// --- Morphology ---
xopen("./geo/Ri18geo.hoc")	// Morphology based on Stuar&Spruston 1998 (Age: P21)
objref ApikalDend, Soma, SomaDend, Axon

ApikalDend = new SectionList()
dend1[28] ApikalDend.subtree()
			

Soma = new SectionList()
for i = 14,27 dend1[i] {Soma.append()}

SomaDend = new SectionList()
dend1[14] SomaDend.subtree()

Axon = new SectionList()
axon Axon.append()
soma Axon.append()
for i=0,13 dend1[i]  {Axon.append()}

double ApikalTrunk[46]  
ApikalTrunk[ 0 ]= 29
ApikalTrunk[ 1 ]= 30
ApikalTrunk[ 2 ]= 31
ApikalTrunk[ 3 ]= 32
ApikalTrunk[ 4 ]= 43
ApikalTrunk[ 5 ]= 44
ApikalTrunk[ 6 ]= 47
ApikalTrunk[ 7 ]= 71
ApikalTrunk[ 8 ]= 72
ApikalTrunk[ 9 ]= 108
ApikalTrunk[ 10 ]= 109
ApikalTrunk[ 11 ]= 110
ApikalTrunk[ 12 ]= 111
ApikalTrunk[ 13 ]= 112
ApikalTrunk[ 14 ]= 126
ApikalTrunk[ 15 ]= 161
ApikalTrunk[ 16 ]= 164
ApikalTrunk[ 17 ]= 165
ApikalTrunk[ 18 ]= 171
ApikalTrunk[ 19 ]= 172
ApikalTrunk[ 20 ]= 173
ApikalTrunk[ 21 ]= 174
ApikalTrunk[ 22 ]= 175
ApikalTrunk[ 23 ]= 176
ApikalTrunk[ 24 ]= 177
ApikalTrunk[ 25 ]= 178
ApikalTrunk[ 26 ]= 179
ApikalTrunk[ 27 ]= 180
ApikalTrunk[ 28 ]= 181
ApikalTrunk[ 29 ]= 182
ApikalTrunk[ 30 ]= 183
ApikalTrunk[ 31 ]= 184
ApikalTrunk[ 32 ]= 185
ApikalTrunk[ 33 ]= 186
ApikalTrunk[ 34 ]= 187
ApikalTrunk[ 35 ]= 188
ApikalTrunk[ 36 ]= 197
ApikalTrunk[ 37 ]= 198
ApikalTrunk[ 38 ]= 199
ApikalTrunk[ 39 ]= 200
ApikalTrunk[ 40 ]= 201
ApikalTrunk[ 41 ]= 202
ApikalTrunk[ 42 ]= 203
ApikalTrunk[ 43 ]= 204
ApikalTrunk[ 44 ]= 206
ApikalTrunk[ 45 ]= 207


// --- Mechanism ---
xopen("./LayerVinit.hoc")

init_General()

init_AxonParameter()
init_SomaParameter()
init_DendParameter()	

init_Axon()
init_Soma()
init_Dend()		

init_Volt()		


print " Layer V - Ri18 successfully built\n"

access dend1[21]	//soma

load_file("./sub/util.hoc")
load_file("./sub/OwnInit.hoc")
load_file("./sub/ReducExp.hoc")