Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996)

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Accession:17663
The experiments and modeling reported in this paper show how intrinsic bursting properties of RE cells may be explained by dendritic calcium currents.
Reference:
1 . Destexhe A, Contreras D, Steriade M, Sejnowski TJ, Huguenard JR (1996) In vivo, in vitro, and computational analysis of dendritic calcium currents in thalamic reticular neurons. J Neurosci 16:169-85 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Thalamus reticular nucleus cell;
Channel(s): I Na,t; I T low threshold; I K; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Bursting; Simplified Models; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Calcium dynamics;
Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Thalamus reticular nucleus cell; I Na,t; I T low threshold; I K; I Sodium; I Calcium; I Potassium;
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dendre
cells
README
capump.mod *
HH2.mod *
IT2.mod
VClamp.mod *
El.oc *
leak.oc *
loc3.oc *
loc80.oc *
locD.oc *
mosinit.hoc *
re1_cc.oc
re3_cc.oc
re3_vc.oc
re80_cc.oc
re80_vc.oc
reD_cc.oc
reD_vc.oc
rundemo.hoc *
                            
/*----------------------------------------------------------------------

  Procedure for localizing T-current in distal dendrites

	- Reconstructed thalamic RE cell with 80 compartments (re80)
	- currents must be localized everywhere

	first parameter: somatic and proximal dendritic conductance
	secnd parameter: medial dendritic conductance
	third parameter: distal dendritic conductance

----------------------------------------------------------------------*/

proc localize() {

	/* CHANGE ALL : */

		forall { gcabar_it2 = $3 }



	/* CHANGE SOMA : */

		soma.gcabar_it2 = $1


	/* CHANGE PROXIMAL SEGMENTS : */

		dend1[0].gcabar_it2 = $1
		dend1[1].gcabar_it2 = $1
		dend1[2].gcabar_it2 = $1
		dend1[22].gcabar_it2 = $1

		dend2[0].gcabar_it2 = $1

		dend3[0].gcabar_it2 = $1

		dend4[0].gcabar_it2 = $1



	/* CHANGE MEDIAL SEGMENTS : */

		dend1[3].gcabar_it2 = $2
		dend1[16].gcabar_it2 = $2
		dend1[17].gcabar_it2 = $2
		dend1[18].gcabar_it2 = $2
		dend1[19].gcabar_it2 = $2
		dend1[23].gcabar_it2 = $2
		dend1[34].gcabar_it2 = $2

		dend2[1].gcabar_it2 = $2
		dend2[4].gcabar_it2 = $2

		dend3[1].gcabar_it2 = $2
		dend3[10].gcabar_it2 = $2

		dend4[1].gcabar_it2 = $2
		dend4[2].gcabar_it2 = $2

}