Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996)

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Accession:17663
The experiments and modeling reported in this paper show how intrinsic bursting properties of RE cells may be explained by dendritic calcium currents.
Reference:
1 . Destexhe A, Contreras D, Steriade M, Sejnowski TJ, Huguenard JR (1996) In vivo, in vitro, and computational analysis of dendritic calcium currents in thalamic reticular neurons. J Neurosci 16:169-85 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Thalamus reticular nucleus cell;
Channel(s): I Na,t; I T low threshold; I K; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Bursting; Simplified Models; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Calcium dynamics;
Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Thalamus reticular nucleus cell; I Na,t; I T low threshold; I K; I Sodium; I Calcium; I Potassium;
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dendre
cells
README
capump.mod *
HH2.mod *
IT2.mod
VClamp.mod *
El.oc *
leak.oc *
loc3.oc *
loc80.oc *
locD.oc *
mosinit.hoc *
re1_cc.oc
re3_cc.oc
re3_vc.oc
re80_cc.oc
re80_vc.oc
reD_cc.oc
reD_vc.oc
rundemo.hoc *
                            
//----------------------------------------------------------------------------
//  define a panel to run the different demos
//----------------------------------------------------------------------------

strdef tstr
ismenu=0
pwmcnt = PWManager[0].count // the initial gui should not be dismissed

objref El

electrodes_present=0	// after electrodes are created they must be
			// destroyed if simulation restarted

proc destroy_elec() {
	execute("objref stim, vc",El)
}

proc restart() {local i

	if (electrodes_present) {
		destroy_elec()
	}

	forall delete_section()

	objref graphItem, save_window_
	for i=0, n_graph_lists-1 {
		graphList[i].remove_all()
	}
	flush_list.remove_all()
	fast_flush_list.remove_all()
	doNotify()
	for (i= PWManager[0].count-1; i >= pwmcnt; i -= 1) {
		PWManager[0].close(i)
		doNotify()
	}
	
	sprint(tstr, "%s.oc", $s1)
	load_file(1, tstr)
}

proc make_demopanel() {
	xpanel("Simulations of TC cells")
// xradiobutton("7", "restart(\"makefig7\")")

	xbutton("Burst behavior in single-compartment model","restart(\"re1_cc\")")
	xbutton("Burst behavior in 3-compartment model","restart(\"re3_cc\")")
        xbutton("Voltage-clamp in 3-compartment cell model","restart(\"re3_vc\")")
        xbutton("Burst behavior in detailed cell model","restart(\"re80_cc\")")
        xbutton("Voltage-clamp in detailed cell model","restart(\"re80_vc\")")
        xbutton("Burst behavior in dissociated cell model","restart(\"reD_cc\")")
        xbutton("Voltage-clamp in dissociated cell model","restart(\"reD_vc\")")
	xpanel()
}

make_demopanel()