"...
We propose a
model in which synaptic strength is the product of
a synapse-specific Hebbian factor and a postsynaptic-
cell-specific homeostatic factor, with each factor
separately arriving at a stable inactive state.
This
model captures ODP dynamics and has plausible
biophysical substrates.
We confirm model predictions
experimentally that plasticity is inactive at
stable states and that synaptic strength overshoots
during recovery from visual deprivation.
..."
Reference:
1 .
Toyoizumi T, Kaneko M, Stryker MP, Miller KD (2014) Modeling the dynamic interaction of Hebbian and homeostatic plasticity. Neuron 84:497-510 [PubMed]
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