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Active zone model of Ca2+ secretion coupling (Keller et al. 2015)
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"... At a large model synapse, the calyx of Held, transmitter release is controlled by several Ca2+ channels in a "domain overlap" mode, at least in young animals. To study the geometrical constraints of Ca2+ channel placement in domain overlap control of release, we used stochastic MCell modelling, at active zones for which the position of docked vesicles was derived from electron microscopy (EM). ..."
Keller D, Babai N, Kochubey O, Han Y, Markram H, Schürmann F, Schneggenburger R (2015) An Exclusion Zone for Ca2+ Channels around Docked Vesicles Explains Release Control by Multiple Channels at a CNS Synapse.
PLoS Comput Biol
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