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CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
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This model simulates the effects of dendritic sodium spikes initiated in distal apical dendrites on the voltage and the calcium dynamics revealed by calcium imaging. It shows that dendritic sodium spike promotes large and transient calcium influxes via NMDA receptor and L-type voltage-gated calcium channels, which contribute to the induction of LTP at distal synapses.
Kim Y, Hsu CL, Cembrowski MS, Mensh BD, Spruston N (2015) Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neurons.
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Neuron or other electrically excitable cell;
Hippocampus CA1 pyramidal GLU cell;
I L high threshold;
Dendritic Action Potentials;
Ion Channel Kinetics;
Detailed Neuronal Models;
Long-term Synaptic Plasticity;
Cembrowski, Mark S [cembrowskim at janelia.hhmi.org];
Hsu, Ching-Lung [hsuc at janelia.hhmi.org];
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Hippocampus CA1 pyramidal GLU cell
I L high threshold
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