CA3 pyramidal neurons: Kv1.2 mediates modulation of cortical inputs (Hyun et al., 2015)

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Accession:184139
This model simulates the contribution of dendritic Na+ and D-type K+ channels to EPSPs at three different locations of apical dendrites, which mimicking innervation sites of mossy fibers (MF), recurrent fibers (AC), and perforant pathway (PP).
Reference:
1 . Hyun JH, Eom K, Lee KH, Bae JY, Bae YC, Kim MH, Kim S, Ho WK, Lee SH (2015) Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 pyramidal cells. J Physiol 593:3617-43 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s): I A; I Sodium; I_KD;
Gap Junctions:
Receptor(s):
Gene(s): Kv1.2 KCNA2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; I A; I Sodium; I_KD;
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HyunEtAl2015
ReadMe.html
Exp2GluSyn.mod
KaProx.mod
KdBG40.mod
Kdr.mod
KhdM01.mod
Na.mod
E807.hoc
Fig7Bb_(IK_conditioned).hoc
Fig7Bb_(IK_control).hoc
Fig7Bc(Gin).hoc
Fig7C_(AC-EPSP).hoc
Fig7C_(MF-EPSP).hoc
Fig7C_(PP-EPSP).hoc
Fig7D_(AC-EPSP).hoc
Fig7D_(MF-EPSP).hoc
Fig7D_(PP-EPSP).hoc
Fig7E_(control).hoc
Fig7E_(lowGkd).hoc
Fig7E_(lowGkdlowGna).hoc
fixnseg.hoc *
L22.hoc
mosinit.hoc
screenshot.png
                            
TITLE K-A channel from Klee Ficker and Heinemann
: modified to account for Dax A Current ----------
: M.Migliore Jun 1997
: The original model results in too big window current, which is robably contamination of D-type current.
: To reduce the window current component, LSH changed vhalfn, zeatan and zetal as follows
: 	1) vhalfn, 0 -> -15 mV
:	2) vhalfl, -60 -> -70 mV
: 	3) zetan, -1.5 -> -3
: 	4) zetal, 3 -> 5 
: To fit these parameters to Kim Jonas (2012), they should be -5, -65, -1.8, 3.7, respectively.


UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
}

PARAMETER {
	v (mV)
	celsius = 24	(degC)
	gbar = .008 (mho/cm2)
    vhalfn = -15    (mV)
    vhalfl = -70  (mV)
    a0l = 0.05    (/ms)
    a0n = 0.05    (/ms)
    zetan = -3    (1)
    zetal = 5  (1)
    gmn = 0.55   (1)
    gml = 1   (1)
	lmin = 6.7 (mS)
	nmin = 0.1 (mS)
	pw = -1    (1)
	tq = -40
	qq = 5
	q10 = 5
	qtl = 0.5
    FRT = 39 (coulombs/joule) 	
}


NEURON {
	SUFFIX KaProx
	USEION k WRITE ik
    RANGE gbar,gka,ik
    GLOBAL ninf,linf,taul,taun,lmin
}

STATE {
	n
    l
}

ASSIGNED {
	ik (mA/cm2)
    ninf
    linf      
    taul
    taun
    gka
}

INITIAL {
	rates(v)
	n=ninf
	l=linf
}

BREAKPOINT {
	SOLVE states METHOD cnexp
	gka = gbar*n*l
	ik = gka*(v+90.0)
}


FUNCTION alpn(v(mV)) {
LOCAL zeta
  zeta = zetan + pw/(1+exp((v-tq)/qq))
  alpn = exp(1.e-3*zeta*(v-vhalfn)*FRT) 
}

FUNCTION betn(v(mV)) {
LOCAL zeta
  zeta = zetan + pw/(1+exp((v-tq)/qq))
  betn = exp(1.e-3*zeta*gmn*(v-vhalfn)*FRT) 
}

FUNCTION alpl(v(mV)) {
  alpl = exp(1.e-3*zetal*(v-vhalfl)*FRT) 
}

FUNCTION betl(v(mV)) {
  betl = exp(1.e-3*zetal*gml*(v-vhalfl)*FRT) 
}

DERIVATIVE states {     : exact when v held constant; integrates over dt step
        rates(v)
        n' = (ninf - n)/taun
        l' = (linf - l)/taul
}

PROCEDURE rates(v (mV)) { :callable from hoc
        LOCAL a,qt
        qt=q10^((celsius-24)/10)
        a = alpn(v)
        ninf = 1/(a+1)
        taun = betn(v)/(qt*a0n*(1+a))
		if (taun<nmin) {taun=nmin}
        a = alpl(v)
        linf = 1/(a+1)
		taul = 0.26*(v+50)/qtl
		: taul = 0.26*v + 13.2, Hoffman Nat 98
		if (taul<lmin/qtl) {taul=lmin/qtl}
}