CA3 pyramidal neurons: Kv1.2 mediates modulation of cortical inputs (Hyun et al., 2015)

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Accession:184139
This model simulates the contribution of dendritic Na+ and D-type K+ channels to EPSPs at three different locations of apical dendrites, which mimicking innervation sites of mossy fibers (MF), recurrent fibers (AC), and perforant pathway (PP).
Reference:
1 . Hyun JH, Eom K, Lee KH, Bae JY, Bae YC, Kim MH, Kim S, Ho WK, Lee SH (2015) Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 pyramidal cells. J Physiol 593:3617-43 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s): I A; I Sodium; I_KD;
Gap Junctions:
Receptor(s):
Gene(s): Kv1.2 KCNA2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; I A; I Sodium; I_KD;
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HyunEtAl2015
ReadMe.html
Exp2GluSyn.mod
KaProx.mod
KdBG40.mod
Kdr.mod
KhdM01.mod
Na.mod
E807.hoc
Fig7Bb_(IK_conditioned).hoc
Fig7Bb_(IK_control).hoc
Fig7Bc(Gin).hoc
Fig7C_(AC-EPSP).hoc
Fig7C_(MF-EPSP).hoc
Fig7C_(PP-EPSP).hoc
Fig7D_(AC-EPSP).hoc
Fig7D_(MF-EPSP).hoc
Fig7D_(PP-EPSP).hoc
Fig7E_(control).hoc
Fig7E_(lowGkd).hoc
Fig7E_(lowGkdlowGna).hoc
fixnseg.hoc *
L22.hoc
mosinit.hoc
screenshot.png
                            
TITLE K-DR channel
: from Klee Ficker and Heinemann
: modified to account for Dax et al.
: M.Migliore 1997
: LSH changed
: 1) gmn from 0.7 to 0.5 to make tau faster
: 2) vhalfn, 13 -> -3.8 (Kim Jonas, 2012) 

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
}

PARAMETER {
	v 		(mV)
	celsius 	(degC)
	gbar	= .003 	(mho/cm2)
    vhalfn	= -3.8   	(mV)
    a0n	= 0.02  (/ms)
    zetan	= -3    (1)
    gmn	= 0.5  	(1)
	nmax	= 2  	(1)
	q10	= 1	(1)
	FRT = 39 (coulombs/joule) 
}

NEURON {
	SUFFIX Kdr
	USEION k WRITE ik
    RANGE  gkdr,gbar,ik
	GLOBAL ninf,taun
}

STATE { n }

ASSIGNED {
	ik 	(mA/cm2)
    ninf	
    gkdr
    taun
}

BREAKPOINT {
	SOLVE states METHOD cnexp
	gkdr 	= gbar * n
	ik 	= gkdr * ( v + 90.0 )
}

INITIAL {
	rates(v)
	n=ninf
}

FUNCTION alpn(v(mV)) {
  alpn = exp( 1.e-3 * zetan * ( v - vhalfn ) * FRT ) 
}

FUNCTION betn(v(mV)) {
  betn = exp( 1.e-3 * zetan * gmn * ( v - vhalfn ) * FRT ) 
}

DERIVATIVE states {     : exact when v held constant; integrates over dt step
        rates(v)
        n' = ( ninf - n ) / taun
}

PROCEDURE rates(v (mV)) { :callable from hoc
        LOCAL a,qt
        qt	= q10 ^ ( ( celsius - 24 ) / 10 )
        a 	= alpn(v)
        ninf 	= 1 / ( 1 + a )
        taun 	= betn(v) / ( qt * a0n * ( 1 + a ) )
	if (taun<nmax) { taun=nmax }
}