Memory savings through unified pre- and postsynaptic STDP (Costa et al 2015)

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Accession:184487
Although it is well known that long-term synaptic plasticity can be expressed both pre- and postsynaptically, the functional consequences of this arrangement have remained elusive. We show that spike-timing-dependent plasticity with both pre- and postsynaptic expression develops receptive fields with reduced variability and improved discriminability compared to postsynaptic plasticity alone. These long-term modifications in receptive field statistics match recent sensory perception experiments. In these simulations we demonstrate that learning with this form of plasticity leaves a hidden postsynaptic memory trace that enables fast relearning of previously stored information, providing a cellular substrate for memory savings. Our results reveal essential roles for presynaptic plasticity that are missed when only postsynaptic expression of long-term plasticity is considered, and suggest an experience-dependent distribution of pre- and postsynaptic strength changes.
Reference:
1 . Costa RP, Froemke RC, Sjöström PJ, van Rossum MC (2015) Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning. Elife [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic GLU cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): NO; Glutamate; Endocannabinoid;
Simulation Environment: MATLAB; Brian; Python;
Model Concept(s): STDP;
Implementer(s): Costa, Rui Ponte [ruipontecosta at gmail.com];
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic GLU cell; NO; Glutamate; Endocannabinoid;
 
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