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Memory savings through unified pre- and postsynaptic STDP (Costa et al 2015)
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Although it is well known that long-term synaptic plasticity can be expressed both pre- and postsynaptically, the functional consequences of this arrangement have remained elusive. We show that spike-timing-dependent plasticity with both pre- and postsynaptic expression develops receptive fields with reduced variability and improved discriminability compared to postsynaptic plasticity alone. These long-term modifications in receptive field statistics match recent sensory perception experiments. In these simulations we demonstrate that learning with this form of plasticity leaves a hidden postsynaptic memory trace that enables fast relearning of previously stored information, providing a cellular substrate for memory savings. Our results reveal essential roles for presynaptic plasticity that are missed when only postsynaptic expression of long-term plasticity is considered, and suggest an experience-dependent distribution of pre- and postsynaptic strength changes.
Costa RP, Froemke RC, Sjöström PJ, van Rossum MC (2015) Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning.
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Neocortex V1 L6 pyramidal corticothalamic GLU cell;
Costa, Rui Ponte [ruipontecosta at gmail.com];
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Neocortex V1 L6 pyramidal corticothalamic GLU cell
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