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Cell signaling/ion channel variability effects on neuronal response (Anderson, Makadia, et al. 2015)
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" ... We evaluated the impact of molecular variability in the expression of cell signaling components and ion channels on electrophysiological excitability and neuromodulation. We employed a computational approach that integrated neuropeptide receptor-mediated signaling with electrophysiology. We simulated a population of neurons in which expression levels of a neuropeptide receptor and multiple ion channels were simultaneously varied within a physiological range. We analyzed the effects of variation on the electrophysiological response to a neuropeptide stimulus. ..."
Anderson WD, Makadia HK, Vadigepalli R (2016) Molecular variability elicits a tunable switch with discrete neuromodulatory response phenotypes.
J Comput Neurosci
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Neuron or other electrically excitable cell;
I L high threshold;
Spike Frequency Adaptation;
Makadia, Hirenkumar K [hiren.makadia at gmail.com];
Anderson, Warren D [warren.anderson at jefferson.edu];
Vadigepalli, Rajanikanth [Rajanikanth.Vadigepalli at jefferson.edu];
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I L high threshold
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