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CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
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This computational study investigates how a CA3 neuronal network consisting of pyramidal cells, basket cells and OLM interneurons becomes epileptic when dendritic inhibition to pyramidal cells is impaired due to the dysfunction of OLM interneurons. After standardizing the baseline activity (theta-modulated gamma oscillations), systematic changes are made in the connectivities between the neurons, as a result of step-wise impairment of dendritic inhibition.
Sanjay M, Neymotin SA, Krothapalli SB (2015) Impaired dendritic inhibition leads to epileptic activity in a computer model of CA3.
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Hippocampus CA3 pyramidal cell;
Hippocampus CA3 interneuron basket cell;
Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
Neymotin, Sam [samn at neurosim.downstate.edu];
Sanjay, M [msanjaycmc at gmail.com];
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Hippocampus CA3 pyramidal cell
Hippocampus CA3 interneuron basket cell
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