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Novel Na current with slow de-inactivation (Tsutsui, Oka 2002)
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The authors found a novel Na current in teleost thalamic nuclei was well described by the m^3 h Hodgkin-Huxley model. The kinetic parameters derived from their experiments (see the reference for details) revealed that the h gate had a large time constant (~100ms at -80 to -50mV). This explains the thalamic neurons long refractory period and the gradual recovery of AP amplitude as the inter spike interval grows.
Tsutsui H, Oka Y (2002) Slow removal of Na(+) channel inactivation underlies the temporal filtering property in the teleost thalamic neurons.
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Teleost thalamic neuron;
Ion Channel Kinetics;
Axonal Action Potentials;
Tsutsui, H ;
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