Inhibition of bAPs and Ca2+ spikes in a multi-compartment pyramidal neuron model (Wilmes et al 2016)

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Accession:187603
"Synaptic plasticity is thought to induce memory traces in the brain that are the foundation of learning. To ensure the stability of these traces in the presence of further learning, however, a regulation of plasticity appears beneficial. Here, we take up the recent suggestion that dendritic inhibition can switch plasticity of excitatory synapses on and off by gating backpropagating action potentials (bAPs) and calcium spikes, i.e., by gating the coincidence signals required for Hebbian forms of plasticity. We analyze temporal and spatial constraints of such a gating and investigate whether it is possible to suppress bAPs without a simultaneous annihilation of the forward-directed information flow via excitatory postsynaptic potentials (EPSPs). In a computational analysis of conductance-based multi-compartmental models, we demonstrate that a robust control of bAPs and calcium spikes is possible in an all-or-none manner, enabling a binary switch of coincidence signals and plasticity. ..."
Reference:
1 . Wilmes KA, Sprekeler H, Schreiber S (2016) Inhibition as a Binary Switch for Excitatory Plasticity in Pyramidal Neurons. PLoS Comput Biol 12:e1004768 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex; Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Neocortex V1 L6 pyramidal corticothalamic GLU cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Dendritic Action Potentials; Synaptic Plasticity; Synaptic Integration;
Implementer(s): Wilmes, Katharina A. [katharina.wilmes at googlemail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; Neocortex V1 L6 pyramidal corticothalamic GLU cell;
#!/usr/bin/env python


"""config-file for traces of Figure 4A"""

# _title_     : config_traces_ca.py
# _author_     : Katharina Anna Wilmes
# _mail_     : katha __at__ bccn-berlin.de


# --Imports--
import os
import gc
import sys
import pickle
import h5py
from time import time
import numpy as np
import datetime

from NeuroTools.parameters import Parameter



#param_ranges = {
#   'Input':
#       {
#       'freq': ParameterArray([10]),
#       'wee':ParameterArray([0.008]),
#       },
#   'Synapse':
#       {
#        'scen': ParameterArray([3]),
#        'shunt_pos':ParameterArray([0,1,2,3])
#       }
#
#   }

params = {
    'visual': 'figure',
    'results_file': 'pairingscenarios',
    'Input':
        {
        'freq': Parameter(10),
        'wee':Parameter(0.008), #0.002
        'wee_strong':Parameter(0.014) #0.002
        },
    'Synapse':
        {
        'scen': Parameter(3),
        'pos': Parameter(3),
        'distal_weight':Parameter(0.00001), #0.01
        'oblique_weight':Parameter(0.00001),
        'basal_weight':Parameter(0.00001),
        'syn_type':'additive',
        'interneuron_frequency': Parameter(75.0),
        'interneuron_reps': Parameter(1),
        },
    'shunt':
        {
        'reversal':Parameter(-73),
        'shunt_pos': Parameter(0),
        'tau1':Parameter(0.5),
        'tau2':Parameter(5),
        'basal_shunt_delay':Parameter(1.5),
        'shunt_delay':Parameter(1.5), 
        'distal_shunt_weight':Parameter(0.05),
        'proximal_shunt_weight':Parameter(0.05),
        'basal_shunt_weight':Parameter(0.05),
        'distal_shunt_pos':Parameter(0.9),
        'proximal_shunt_pos':Parameter(0.18),
        'basal_shunt_pos':Parameter(0.3),
        'distal_shunt_compartment':'a',
        'proximal_shunt_compartment':'a',
        'basal_shunt_compartment':'basal',
        },
   'STDP':
       {
       'delta_t': Parameter(4,'ms'),
       'thresh' : Parameter(-30, 'mV'),
       'ca_thresh' : Parameter(0.5, 'mM')
       },
   'cell':
        {
        'gsca' : Parameter(1.5),
        'git2' : Parameter(0.005),
        'gbar_kca' : Parameter(2.5),
        },
    'sim':
        {
        'duration' : Parameter(1,'second'),
        'v_init': Parameter(-70,'mV'),
        'dt': Parameter(0.1,'ms'),
        'sim_time':Parameter(100,'ms'), 
        'celsius': Parameter(30,'C'),
        'high_res': True,
        'theta':Parameter(1,'1/ms')
        },
    'plot':
        {
        'version':Parameter(1),
        'path': os.path.expanduser("/scratch/kwilmes/Project1")
        }
}