Multiplication by NMDA receptors in Direction Selective Ganglion cells (Poleg-Polsky & Diamond 2016)

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Accession:189347
The model demonstrates how signal amplification with NMDARs depends on the synaptic environment. When direction selectivity (DS) detection is mediated by DS inhibition, NMDARs multiply other synaptic conductances. In the case of DS tuned excitation, NMDARs contribute additively.
Reference:
1 . Poleg-Polsky A, Diamond JS (2016) NMDA Receptors Multiplicatively Scale Visual Signals and Enhance Directional Motion Discrimination in Retinal Ganglion Cells. Neuron 89:1277-1290 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Dendrite; Neuron or other electrically excitable cell; Realistic Network; Synapse;
Brain Region(s)/Organism:
Cell Type(s): Retina ganglion GLU cell;
Channel(s): I K; I Na,t;
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA; Nicotinic;
Gene(s):
Transmitter(s): Glutamate; Acetylcholine; Gaba;
Simulation Environment: NEURON;
Model Concept(s): Direction Selectivity; Synaptic Integration; Vision;
Implementer(s): Polsky, Alon [alonpol at tx.technion.ac.il];
Search NeuronDB for information about:  Retina ganglion GLU cell; Nicotinic; GabaA; AMPA; NMDA; I Na,t; I K; Acetylcholine; Gaba; Glutamate;