Signaling pathways underlying LTP in hippocampal CA1 pyramidal cells (Jedrzejewska-Szmek et al 2017)

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Accession:190304
" ...We investigated whether the diverse experimental evidence can be unified by creating a spatial, mechanistic model of multiple signaling pathways in hippocampal CA1 neurons. Our results show that the combination of activity of several key kinases can predict the occurrence of long-lasting forms of LTP for multiple experimental protocols. ..."
Reference:
1 . J?drzejewska-Szmek J, Luczak V, Abel T, Blackwell KT (2017) ß-adrenergic signaling broadly contributes to LTP induction. PLoS Comput Biol 13:e1005657 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Ephinephrine;
Simulation Environment: NeuroRD;
Model Concept(s): Long-term Synaptic Plasticity; Signaling pathways;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Jedrzejewska-Szmek, Joanna ;
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; Ephinephrine;
 
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PLoSCompBiol2017
model_files
fig_12
long_dend
model_100_percent
model_120_percent
model_70_percent
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