MicrocircuitDB: Signaling pathways underlying LTP in hippocampal CA1 pyramidal cells (Jedrzejewska-Szmek et al 2017)

Signaling pathways underlying LTP in hippocampal CA1 pyramidal cells (Jedrzejewska-Szmek et al 2017)

Download zip file
Help downloading and running models

Model Information
Model File
Versions

Accession:190304

" ...We investigated whether the diverse experimental evidence can be unified by creating a spatial, mechanistic model of multiple signaling pathways in hippocampal CA1 neurons. Our results show that the combination of activity of several key kinases can predict the occurrence of long-lasting forms of LTP for multiple experimental protocols. ..."
Reference:
1 . J?drzejewska-Szmek J, Luczak V, Abel T, Blackwell KT (2017) ß-adrenergic signaling broadly contributes to LTP induction. PLoS Comput Biol 13:e1005657 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:	Synapse;
Brain Region(s)/Organism:
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):	Ephinephrine;
Simulation Environment:	NeuroRD;
Model Concept(s):	Long-term Synaptic Plasticity; Signaling pathways;
Implementer(s):	Blackwell, Avrama [avrama at gmu.edu]; Jedrzejewska-Szmek, Joanna ;