Geometry-induced features of current transfer in neuronal dendrites (Korogod, Kulagina 1998)

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Accession:19214
The impact of dendritic geometry on somatopetal transfer of the current generated by steady uniform activation of excitatory synaptic conductance distributed over passive, or active (Hodgkin-Huxley type), dendrites was studied in simulated neurons.
Reference:
1 . Korogod SM, Kulagina IB (1998) Geometry-induced features of current transfer in neuronal dendrites with tonically activated conductances. Biol Cybern 79:231-40 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites; Influence of Dendritic Geometry;
Implementer(s): Korogod, Sergey M [Korogod at ff.dsu.dp.ua]; Kulagina, Irina B [Kulagina at ff.dsu.dp.ua]; Kukushka, Valery I [Valery at ff.dsu.dp.ua];
Search NeuronDB for information about:  I Na,t; I K;
// Geometry-induced features of current transfer in neuronal dendrites with tonically activated conductances
// Sergey M. Korogod, Irina B. Kulagina
// Biol. Cybern. 79, 231-240 (1998)

objectvar TRGraph
objectvar Stim

// define membrane mechanisms
proc SetMembrane() {
  strdef OutLine
  OutLine = "Soma {insert PasSA}"
  execute1(OutLine)
  for i=0, 2 {
    sprint(OutLine, "Dendrite[%d] {insert PasD gs_PasD = 0.0}", i)
    execute1(OutLine)
  }
} // SetMembrane()

func CalcT() { local T
  T = (v($1) - erev_PasD($1)) / 10
  return T
} // CalcT()

// make graphics for Fig.4. D (asymmetric)
proc MakeTRGraph() {
  strdef OutLine
  TRGraph = new Graph(0)
  TRGraph.xaxis()
  TRGraph.yaxis()
  RRGraph = new RangeVarPlot("CalcT($1)")
  OutLine = "Dendrite[0] RRGraph.begin(0) Dendrite[1] RRGraph.end(1)"
  execute1(OutLine)
  TRGraph.addobject(RRGraph, 1, 1, 1, 1)
  RRGraph = new RangeVarPlot("CalcT($1)")
  OutLine = "Dendrite[0] RRGraph.begin(0) Dendrite[2] RRGraph.end(1)"
  execute1(OutLine)
  TRGraph.addobject(RRGraph, 1, 1, 1, 1)
  TRGraph.size(0, 800, 0.5, 1)
  TRGraph.view(0, 0.5, 800, 0.5, 360, 269, 385, 250)
  TRGraph.label(0.5, 1, "D", 2, 1, 0, 1, 1)
  TRGraph.label(0.05, 1, "T(x)", 2, 1, 0, 1, 1)
  TRGraph.label(0.9, 0.15, "um", 2, 1, 0, 1, 1)
  flush_list.append(TRGraph)
  TRGraph.save_name("flush_list.")
  objectvar RRGraph
} // MakeTRGraph()

proc Destroy() {
  objectvar Stim
  TRGraph.unmap()
} // Destroy()

proc MainExec() {
  GetModelTopology(5)
  SetMembrane()
  OutLine = "access Soma"
  execute1(OutLine)
  OutLine = "Soma Stim = new IClamp(0.75)"
  execute1(OutLine)
  OutLine = "Stim.del = 0"
  execute1(OutLine)
  OutLine = "Stim.dur = 50"
  execute1(OutLine)
  OutLine = "Stim.amp = 0.169"
  execute1(OutLine)
  tstop = 50
  MakeTRGraph()
} // MainExec()

MainExec()