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Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
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"Corticospinal neurons (SPI), thick-tufted pyramidal neurons in motor cortex layer 5B that project caudally via the medullary pyramids, display distinct class-specific electrophysiological properties in vitro: strong sag with hyperpolarization, lack of adaptation, and a nearly linear frequency-current (FI) relationship. We used our electrophysiological data to produce a pair of large archives of SPI neuron computer models in two model classes: 1. Detailed models with full reconstruction; 2. Simplified models with 6 compartments. We used a PRAXIS and an evolutionary multiobjective optimization (EMO) in sequence to determine ion channel conductances. ..."
Neymotin SA, Suter BA, Dura-Bernal S, Shepherd GM, Migliore M, Lytton WW (2017) Optimizing computer models of corticospinal neurons to replicate in vitro dynamics.
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Neuron or other electrically excitable cell;
Neocortex M1 L5B pyramidal pyramidal tract GLU cell;
Neocortex primary motor area pyramidal layer 5 corticospinal cell;
I L high threshold;
Detailed Neuronal Models;
Suter, Benjamin ;
Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org];
Dura-Bernal, Salvador [salvadordura at gmail.com];
Forzano, Ernie ;
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Neocortex M1 L5B pyramidal pyramidal tract GLU cell
I L high threshold
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