HH model neuron of the Suprachiasmatic Nucleus including a persistent Na+ channel (Paul et al 2016)

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Accession:196197
Hodgkin-Huxley style model for a neuron of the Suprachiasmatic Nucleus (SCN). Modified from DeWoskin et al, PNAS, 2015 to include a persistent sodium current. The model is used to study the role of the kinase GSK3 in regulating the electrical activity of SCN neurons through a persistent sodium current.
Reference:
1 . Paul JR, DeWoskin D, McMeekin LJ, Cowell RM, Forger DB, Gamble KL (2016) Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability. Nat Commun 7:13470 [PubMed]
2 . DeWoskin D, Myung J, Belle MD, Piggins HD, Takumi T, Forger DB (2015) Distinct roles for GABA across multiple timescales in mammalian circadian timekeeping. Proc Natl Acad Sci U S A 112:E3911-9 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Suprachiasmatic nucleus (SCN) neuron;
Channel(s): I Na,p; I Calcium; I K,Ca; I K,leak; I Na, leak;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s):
Implementer(s): DeWoskin, Daniel [dadewoskin at gmail.com] ;
Search NeuronDB for information about:  I Na,p; I K,leak; I K,Ca; I Calcium; I Na, leak;
 
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PaulEtAl20916
                            
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