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HH model neuron of the Suprachiasmatic Nucleus including a persistent Na+ channel (Paul et al 2016)
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Hodgkin-Huxley style model for a neuron of the Suprachiasmatic Nucleus (SCN). Modified from DeWoskin et al, PNAS, 2015 to include a persistent sodium current. The model is used to study the role of the kinase GSK3 in regulating the electrical activity of SCN neurons through a persistent sodium current.
Paul JR, DeWoskin D, McMeekin LJ, Cowell RM, Forger DB, Gamble KL (2016) Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability.
DeWoskin D, Myung J, Belle MD, Piggins HD, Takumi T, Forger DB (2015) Distinct roles for GABA across multiple timescales in mammalian circadian timekeeping.
Proc Natl Acad Sci U S A
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Neuron or other electrically excitable cell;
Suprachiasmatic nucleus (SCN) neuron;
I Na, leak;
DeWoskin, Daniel [dadewoskin at gmail.com] ;
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I Na, leak
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