CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:20212
We developed a CA1 pyramidal cell model calibrated with a broad spectrum of in vitro data. Using simultaneous dendritic and somatic recordings, and combining results for two different response measures (peak vs. mean EPSP), two different stimulus formats (single shock vs. 50 Hz trains), and two different spatial integration conditions (within vs. between-branch summation), we found the cell's subthreshold responses to paired inputs are best described as a sum of nonlinear subunit responses, where the subunits correspond to different dendritic branches. In addition to suggesting a new type of experiment and providing testable predictions, our model shows how conclusions regarding synaptic arithmetic can be influenced by an array of seemingly innocuous experimental design choices.
Reference:
1 . Poirazi P, Brannon T, Mel BW (2003) Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron 37:977-87 [PubMed]
2 . Poirazi P, Brannon T, Mel BW (2003) Pyramidal neuron as two-layer neural network. Neuron 37:989-99 [PubMed]
3 . Poirazi P, Brannon T, Mel BW (2003ab-sup) Online Supplement: About the Model Neuron 37 Online:1-20
4 . Polsky A, Mel BW, Schiller J (2004) Computational subunits in thin dendrites of pyramidal cells. Nat Neurosci 7:621-7 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s): GabaA; GabaB; NMDA; Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Activity Patterns; Dendritic Action Potentials; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Depression; Delay;
Implementer(s): Poirazi, Panayiota [poirazi at imbb.forth.gr];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; GabaB; NMDA; Glutamate; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium;
/
CA1_multi
template
BasalPath.hoc *
EPSPTuning.hoc *
ExperimentControl.hoc *
load_templates.hoc *
load_templates.hoc~
ObliquePath.hoc *
RangeRef.hoc *
SynapseBand.hoc *
                            
// This template creates the Basal Path lists, starting from the
// section attached to the trunk and ending with the basal tip section 
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

begintemplate BasalPath

public basal_dtrunk_to_tip, basal_trunk_section, root_basal

strdef sexec

objref basal_trunk_section
strdef basal_trunk_section_name

objref root_basal
strdef root_basal_name

objref basal_tip_section
strdef basal_tip_section_name

objref basal_path

proc init () {
  sec_count=0

  forsec $o1 {

    if (sec_count==1) {
       root_basal    = new SectionRef()
       root_basal_name=secname()
    }
      
    if (!sec_count) {
       distance(0,1)
       basal_trunk_section  = new SectionRef()
       basal_trunk_section_name=secname()
      }
    sec_count=sec_count+1

    basal_tip_section    = new SectionRef()
    basal_tip_section_name=secname()
  }

  access root_basal.sec
  distance(0,0)
  access basal_tip_section.sec
  basal_dtrunk_to_tip=distance(1,1)

//printf("BasalPath basal_trunk_section: %s root_basal: %s basal_tip_section: %s distance between root_basal and basal_tip_section: %g\n", basal_trunk_section_name, root_basal_name, basal_tip_section_name, basal_dtrunk_to_tip)
}

endtemplate BasalPath