CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)

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Accession:206244
In our experimental study, we combined paired patch-clamp recordings and two-photon Ca2+ imaging to quantify inhibition exerted by individual GABAergic contacts on hippocampal pyramidal cell dendrites. We observed that Ca2+ transients from back-propagating action potentials were significantly reduced during simultaneous activation of individual nearby GABAergic synapses. To simulate dendritic Ca2+ inhibition by individual GABAergic synapses, we employed a multi-compartmental CA1 pyramidal cell model with detailed morphology, voltage-gated channel distributions, and calcium dynamics, based with modifications on the model of Poirazi et al., 2003, modelDB accession # 20212.
Reference:
1 . Müllner FE, Wierenga CJ, Bonhoeffer T (2015) Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time. Neuron 87:576-89 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Calcium; I Sodium; I Potassium; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Dendritic Action Potentials; Active Dendrites; Calcium dynamics;
Implementer(s): Muellner, Fiona E [fiona.muellner at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I h; I Sodium; I Calcium; I Potassium; Gaba;
// For each section location, define x,y,z coordinates so it can be
// displayed in 3-D

proc endpt() {
  P=(n3d()-1)*$1

  x_d3($1)=x3d(P)
  y_d3($1)=y3d(P)
  z_d3($1)=z3d(P)

}
proc fracpt() { local posn, A
  A=$1
  posn=$2
  x_d3(posn)=x3d(i-1) + (x3d(i) - x3d(i-1))*A
  y_d3(posn)=y3d(i-1) + (y3d(i) - y3d(i-1))*A
  z_d3(posn)=z3d(i-1) + (z3d(i) - z3d(i-1))*A

}
proc map_segments_to_3d() {

    forall {
    
    insert d3
    i=0
    endpt(0)

    for (x) {if (x > 0 && x < 1) {

      while (arc3d(i)/L < x) {
        i += 1
      }
      D=arc3d(i) - arc3d(i-1)
      if (D <= 0) {
      printf("\t\t * %s had a D < 0\n", secname())
      }
      alpha = (x*L - arc3d(i-1))/D
      fracpt(alpha,x)

    }}
    endpt(1)

  }
}