CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)

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Accession:206244
In our experimental study, we combined paired patch-clamp recordings and two-photon Ca2+ imaging to quantify inhibition exerted by individual GABAergic contacts on hippocampal pyramidal cell dendrites. We observed that Ca2+ transients from back-propagating action potentials were significantly reduced during simultaneous activation of individual nearby GABAergic synapses. To simulate dendritic Ca2+ inhibition by individual GABAergic synapses, we employed a multi-compartmental CA1 pyramidal cell model with detailed morphology, voltage-gated channel distributions, and calcium dynamics, based with modifications on the model of Poirazi et al., 2003, modelDB accession # 20212.
Reference:
1 . Müllner FE, Wierenga CJ, Bonhoeffer T (2015) Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time. Neuron 87:576-89 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Calcium; I Sodium; I Potassium; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Dendritic Action Potentials; Active Dendrites; Calcium dynamics;
Implementer(s): Muellner, Fiona E [fiona.muellner at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; I h; I Sodium; I Calcium; I Potassium; Gaba;
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CA1_multi
mechanism
previously used
ampa.mod *
cad.mod
cagk.mod *
cal.mod *
calH.mod *
cat.mod
cldif.mod
d3.mod *
gabaA_Cl.mod
h.mod *
hha_old.mod *
hha2.mod *
kadist.mod *
kaprox.mod *
kca.mod *
km.mod *
nap.mod *
nmda.mod *
                            
TITLE  Na persistent channel
: used in distal oblique dendrites to assist Ca spike initiation  
: a typo in the exponential function was pointed out by Michele Migliore and
: corrected by Yiota Poirazi on December 4th, 2003
NEURON {
	SUFFIX nap
	USEION na READ ena WRITE ina
        RANGE  gnabar,vhalf, K

}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)

}

INDEPENDENT {t FROM 0 TO 1 WITH 100 (ms)}

PARAMETER {                         : parameters that can be entered when function is called in cell-setup 
        dt (ms) 
	v (mV)
        ena = 50           (mV)     : Na reversal potential  (reset in cell-setup.hoc)
	K = 4.5            (1)      : slope of steady state variable
:	gnabar = 0.001e-2 (mho/cm2) : suggested conductance, 1 percent of the transient Na current
	gnabar = 0                  : initialized conductance
	vhalf  = -50.4    (mV)      : half potential
}	

STATE { n }

ASSIGNED {
	ina (mA/cm2)
}

INITIAL {
:	SOLVE states
}

BREAKPOINT {
	SOLVE states
	ina = gnabar*n*n*n*(v-ena)
}

PROCEDURE states() {     : exact when v held constant; integrates over dt step

:        n = 1 / (1 + (exp(vhalf - v))/K) : steady state value !!!typo in the exponential function!!!

        n = 1 / (1 + (exp(vhalf - v)/K)) : steady state value
        VERBATIM
        return 0;
        ENDVERBATIM
}