CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)

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In our experimental study, we combined paired patch-clamp recordings and two-photon Ca2+ imaging to quantify inhibition exerted by individual GABAergic contacts on hippocampal pyramidal cell dendrites. We observed that Ca2+ transients from back-propagating action potentials were significantly reduced during simultaneous activation of individual nearby GABAergic synapses. To simulate dendritic Ca2+ inhibition by individual GABAergic synapses, we employed a multi-compartmental CA1 pyramidal cell model with detailed morphology, voltage-gated channel distributions, and calcium dynamics, based with modifications on the model of Poirazi et al., 2003, modelDB accession # 20212.
1 . Müllner FE, Wierenga CJ, Bonhoeffer T (2015) Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time. Neuron 87:576-89 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Calcium; I Sodium; I Potassium; I h;
Gap Junctions:
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Dendritic Action Potentials; Active Dendrites; Calcium dynamics;
Implementer(s): Muellner, Fiona E [fiona.muellner at];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I h; I Sodium; I Calcium; I Potassium; Gaba;
BasalPath.hoc *
ExperimentControl.hoc *
ObliquePath.hoc *
// This template creates the Basal Path lists, starting from the
// section attached to the trunk and ending with the basal tip section 
// written by Yiota Poirazi, July 2001,

begintemplate BasalPath

public basal_dtrunk_to_tip, basal_trunk_section, root_basal

strdef sexec

objref basal_trunk_section
strdef basal_trunk_section_name

objref root_basal
strdef root_basal_name

objref basal_tip_section
strdef basal_tip_section_name

objref basal_path

proc init () {

  forsec $o1 {

    if (sec_count==1) {
       root_basal    = new SectionRef()
    if (!sec_count) {
       basal_trunk_section  = new SectionRef()

    basal_tip_section    = new SectionRef()

  access root_basal.sec
  access basal_tip_section.sec

//printf("BasalPath basal_trunk_section: %s root_basal: %s basal_tip_section: %s distance between root_basal and basal_tip_section: %g\n", basal_trunk_section_name, root_basal_name, basal_tip_section_name, basal_dtrunk_to_tip)

endtemplate BasalPath