" ... We quantified BDNF’s effect on
cultured cortical neuron morphological parameters and found that BDNF stimulates
dendrite growth and addition of dendrites while increasing both excitatory and inhibitory
presynaptic inputs in a spatially restricted manner. To gain insight into how these
combined changes in neuron structure and synaptic input impact AP generation, we
used the morphological parameters we gathered to generate computational models.
Simulations suggest that BDNF-induced neuron morphologies generate more APs
under a wide variety of conditions. ..."
Galati DF, Hiester BG, Jones KR (2016) Computer Simulations Support a Morphological Contribution to BDNF Enhancement of Action Potential Generation. Front Cell Neurosci 10:209 [PubMed]
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