"Developing networks of neural systems can exhibit spontaneous,
synchronous activities called neural bursts, which can be important in
the organization of functional neural circuits.
Using a propagation model we infer the spreading
speed of the spiking activity, which increases as the culture ages.
perform computer simulations of the system using a physiological model
of spiking networks in two spatial dimensions and find the parameters
that reproduce the observed resynchronization of spiking in the
An analysis of the simulated dynamics suggests that the
depletion of synaptic resources causes the resynchronization.
The spatial propagation dynamics of the simulations match well with
observations over the course of a burst and point to an interplay of
the synaptic efficacy and the noisy neural self-activation in
producing the morphology of the bursts."
Huang CH, Huang YT, Chen CC, Chan CK (2017) Propagation and synchronization of reverberatory bursts in developing cultured networks. J Comput Neurosci 42:177-185 [PubMed]