"... In order to
investigate the respective roles of synaptic interactions and
nonsynaptic mechanisms in seizure transitions, we developed a
computational model of hippocampal cells, involving the extracellular
space, realistic dynamics of Na+, K+, Ca2+ and Cl - ions, glial uptake
and extracellular diffusion mechanisms. We show that the network
behavior with fixed ionic concentrations may be quite different from
the neurons’ behavior when more detailed modeling of ionic dynamics is
included. In particular, we show that in the extended model strong
discharge of inhibitory interneurons may result in long lasting
accumulation of extracellular K+, which sustains the depolarization of
the principal cells and causes their pathological discharges.
..."
Reference:
1 .
Gentiletti D, Suffczynski P, Gnatkovsky V, de Curtis M (2017) Changes of Ionic Concentrations During Seizure Transitions - A Modeling Study. Int J Neural Syst 27:1750004 [PubMed]
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