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Distance-dependent synaptic strength in CA1 pyramidal neurons (Menon et al. 2013)
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Menon et al. (2013) describes the experimentally-observed variation in synaptic AMPA and NMDA conductance as a function of distance from the soma. This model explores the effect of this variation on somatic EPSPs and dendritic spike initiation, as compared to the case of uniform AMPA and NMDA conductance.
Menon V, Musial TF, Liu A, Katz Y, Kath WL, Spruston N, Nicholson DA (2013) Balanced synaptic impact via distance-dependent synapse distribution and complementary expression of AMPARs and NMDARs in hippocampal dendrites.
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Neuron or other electrically excitable cell;
Hippocampus CA1 pyramidal GLU cell;
I Na, slow inactivation;
Menon, Vilas [vilasmenon2008 at u dot northwestern dot edu];
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Hippocampus CA1 pyramidal GLU cell
I Na, slow inactivation
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