Interneuron Specific 3 Interneuron Model (Guet-McCreight et al, 2016)

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Accession:223031
In this paper we develop morphologically detailed multi-compartment models of Hippocampal CA1 interneuron specific 3 interneurons using cell current-clamp recordings and dendritic calcium imaging data. In doing so, we developed several variant models, as outlined in the associated README.html file.
Reference:
1 . Guet-McCreight A, Camiré O, Topolnik L, Skinner FK (2016) Using a Semi-Automated Strategy to Develop Multi-Compartment Models That Predict Biophysical Properties of Interneuron-Specific 3 (IS3) Cells in Hippocampus. eNeuro [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s):
Channel(s): I Na,t; I Na,p; I A;
Gap Junctions:
Receptor(s):
Gene(s): Kv3.1 KCNC1; Kv2.1 KCNB1;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Active Dendrites; Activity Patterns; Depolarization block; Detailed Neuronal Models; Ion Channel Kinetics;
Implementer(s): Guet-McCreight, Alexandre [alexandre.guet.mccreight at mail.utoronto.ca];
Search NeuronDB for information about:  I Na,p; I Na,t; I A;
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Guet-McCreightEtAl2016
S1
IKa.mod *
Ikdrf.mod *
Ikdrs.mod *
ingauss.mod *
Nap.mod *
Nasoma.mod *
init.hoc
IS3_S1_TopModel.hoc
                            
load_file("IS3_S1_TopModel.hoc")
load_file("nrngui.hoc")
	
//Create Graph & Keep Lines
objectvar save_window_, rvp_
objectvar scene_vector_[3]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
ocbox_list_ = new List()
scene_list_ = new List()
pwman_place(0,0,0)
save_window_ = new Graph(0)
save_window_.size(0,tstop,-120,40)
scene_vector_[2] = save_window_
save_window_.view(0, -120, tstop, 160, 414, 23, 300.48, 200.32)
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
objectvar scene_vector_[1]
save_window_.exec_menu("Keep Lines")

// Apply IClamp at soma and run current injection protocol
objectvar stim
access soma
stim = new IClamp(0.5)
stim.del = 250
stim.dur = 800
save_window_.addexpr("-100 pA","v(.5)", 2, 1, 0.8, 0.9, 2)
stim.amp = -0.1
run()
save_window_.addexpr("20 pA","v(.5)", 4, 1, 0.8, 0.9, 2)
stim.amp = 0.02
run()
save_window_.addexpr("50 pA","v(.5)", 3, 1, 0.8, 0.9, 2)
stim.amp = 0.05
run()
save_window_.addexpr("500 pA","v(.5)", 5, 1, 0.8, 0.9, 2)
stim.amp = 0.5
run()