Glutamate-evoked Ca2+ oscillations in single astrocytes (Modified from Dupont et al. 2011)

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Accession:223274
We tested the reproducibility and comparability of four astrocyte models (Manninen, Havela, Linne, 2017). Model by Dupont et al. (2011) was one of them, but we had to modify the model to get more similar results as in the original publication. We implemented and ran the modified model using Jupyter Notebook. Model code produces results of Figure 1 and Figures 3-5 in Manninen, Havela, Linne (2017).
Reference:
1 . Manninen T, Havela R, Linne ML (2017) Reproducibility and comparability of computational models for astrocyte calcium excitability Front. Neuroinform.
2 . Dupont G, Lokenye EF, Challiss RA (2011) A model for Ca2+ oscillations stimulated by the type 5 metabotropic glutamate receptor: an unusual mechanism based on repetitive, reversible phosphorylation of the receptor. Biochimie 93:2132-8 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Glia;
Brain Region(s)/Organism: Generic;
Cell Type(s): Astrocyte;
Channel(s):
Gap Junctions:
Receptor(s): IP3; mGluR5;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: Python;
Model Concept(s): Calcium dynamics; Oscillations; Signaling pathways;
Implementer(s): Manninen, Tiina [tiina.h.manninen at gmail.com];
Search NeuronDB for information about:  mGluR5; IP3; Glutamate;
 
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ModifiedDupont2011
                            
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