Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)

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Accession:223649
" ... We hypothesized that currents are grouped into distinct modules that shape specific neuronal characteristics or signatures, such as resting potential, sub-threshold oscillations, and spiking waveforms, for several classes of neurons. For such a grouping to occur, the currents within one module should have minimal functional interference with currents belonging to other modules. This condition is satisfied if the gating functions of currents in the same module are grouped together on the voltage axis; in contrast, such functions are segregated along the voltage axis for currents belonging to different modules. We tested this hypothesis using four published example case models and found it to be valid for these classes of neurons. ..."
Reference:
1 . Alturki A, Feng F, Nair A, Guntu V, Nair SS (2016) Distinct current modules shape cellular dynamics in model neurons. Neuroscience 334:309-331 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus; Amygdala;
Cell Type(s): Abstract single compartment conductance based cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Activity Patterns; Oscillations; Methods; Olfaction;
Implementer(s):
/
AlturkiEtAl2016
3_Mitral
Original
Segregated
readme_Rubin_and_Cleland_2006.txt
                            
This is to replicate Fig.A3B in Alturki et al., 2016

ORIGINAL
To run the original model of Rubin and Cleland:
1- Click on mosinit.hoc.
2- In the long poped-up window, click on the third icon from top (Figure 2A Bottom).
	* This is the same plot that we show in figure A3 (middle trace).
	* The injected current is 200 pA, and duration is 1200 ms.

SEGREGATED
To run the segregated model of Rubin and Cleland:
1- Click on mosinit.hoc.
2- In the long poped-up window, click on the third icon from top (Figure 2A Bottom).
	* This is the same plot that we show in figure A3 of Alturki et al. 2016 (middle trace).
	* The injected current is 200 pA, and duration is 1200 ms.

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TO COMPILE AND RUN THE MODEL IN THE FOLDERS 'ORIGINAL' OR 'SEGREGATED' DO THE FOLLOWING:

Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui FILENAME.hoc

Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
FILENAME.hoc 
will open the simulation window.

Under MAC OS X:
Drag and drop the FILE folder onto the mknrndll icon in the NEURON
application folder. When the mod files are finished compiling, double click on the simulation file FILENAME.hoc