Model of CA1 activity during working memory task (Spera et al. 2016)

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Accession:223962
"The cellular processes underlying individual differences in the Woring Memory Capacity (WMC) of humans are essentially unknown. Psychological experiments suggest that subjects with lower working memory capacity (LWMC), with respect to subjects with higher capacity (HWMC), take more time to recall items from a list because they search through a larger set of items and are much more susceptible to interference during retrieval. ... In this paper, we investigate the possible underlying mechanisms at the single neuron level by using a computational model of hippocampal CA1 pyramidal neurons, which have been suggested to be deeply involved in the recognition of specific items. ..."
Reference:
1 . Spera E, Migliore M, Unsworth N, Tegolo D (2016) On the cellular mechanisms underlying working memory capacity in humans Neural Network World 4:335-359
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Synapse;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Working memory;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell;
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SperaEtAl2016
readme.txt
distr.mod *
Gfluct.mod
h.mod *
kadist.mod *
kaprox.mod *
kdrca1.mod *
na3n.mod *
naxn.mod *
netstims.mod *
fixnseg.hoc *
geoc91662.hoc *
mosinit.hoc
obliqui91662.txt
simulation91662.hoc
                            
TITLE ...just to store peak membrane voltage
: M.Migliore June 2001

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)

}

PARAMETER {
	v (mV)
}


NEURON {
	SUFFIX ds
        RANGE vmax
}

ASSIGNED {
	vmax
}

INITIAL {
	vmax=v
}


BREAKPOINT {
	if (v>vmax) {vmax=v}
}