Model for K-ATP mediated bursting in mSNc DA neurons (Knowlton et al 2018)

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Accession:227678
"Burst firing in medial substantia nigra dopamine (mSN DA) neurons has been selectively linked to novelty-induced exploration behavior in mice. Burst firing in mSN DA neurons, in contrast to lateral SN DA neurons, requires functional ATP-sensitive potassium channels (K-ATP) both in vitro and in vivo. However, the precise role of K-ATP channels in promoting burst firing is un-known. We show experimentally that L-type calcium channel activity in mSN DA neurons en-hances open probability of K-ATP channels. We then generated a mathematical model to study the role of Ca2+ dynamics driving K-ATP channel function in mSN DA neurons during bursting. ..."
Reference:
1 . Knowlton C, Kutterer S, Roeper J, Canavier CC (2018) Calcium dynamics control K-ATP channel-mediated bursting in substantia nigra dopamine neurons: a combined experimental and modeling study. J Neurophysiol 119:84-95 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Substantia nigra pars compacta DA cell;
Channel(s): ATP-senstive potassium current; I Calcium; I Sodium; Ca pump; I K;
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program;
Model Concept(s): Calcium dynamics; Ion Channel Kinetics; Bursting;
Implementer(s): Canavier, CC; Knowlton, Christopher [cknow1 at lsuhsc.edu];
Search NeuronDB for information about:  Substantia nigra pars compacta DA cell; NMDA; I K; I Sodium; I Calcium; ATP-senstive potassium current; Ca pump;
 
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