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Model for K-ATP mediated bursting in mSNc DA neurons (Knowlton et al 2018)
 
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Accession:
227678
"Burst firing in medial substantia nigra dopamine (mSN DA) neurons has been selectively linked to novelty-induced exploration behavior in mice. Burst firing in mSN DA neurons, in contrast to lateral SN DA neurons, requires functional ATP-sensitive potassium channels (K-ATP) both in vitro and in vivo. However, the precise role of K-ATP channels in promoting burst firing is un-known. We show experimentally that L-type calcium channel activity in mSN DA neurons en-hances open probability of K-ATP channels. We then generated a mathematical model to study the role of Ca2+ dynamics driving K-ATP channel function in mSN DA neurons during bursting. ..."
Reference:
1 .
Knowlton C, Kutterer S, Roeper J, Canavier CC (2018) Calcium dynamics control K-ATP channel-mediated bursting in substantia nigra dopamine neurons: a combined experimental and modeling study.
J Neurophysiol
119
:84-95
[
PubMed
]
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Model Information
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Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Basal ganglia;
Cell Type(s):
Substantia nigra pars compacta DA cell;
Channel(s):
ATP-senstive potassium current;
I Calcium;
I Sodium;
Ca pump;
I K;
Gap Junctions:
Receptor(s):
NMDA;
Gene(s):
Transmitter(s):
Simulation Environment:
C or C++ program;
Model Concept(s):
Calcium dynamics;
Ion Channel Kinetics;
Bursting;
Implementer(s):
Canavier, CC;
Knowlton, Christopher [cknow1 at lsuhsc.edu];
Search NeuronDB
for information about:
Substantia nigra pars compacta DA cell
;
NMDA
;
I K
;
I Sodium
;
I Calcium
;
ATP-senstive potassium current
;
Ca pump
;
/
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