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Model for concentration invariant odor coding based on primacy hypothesis (Wilson et al 2017)
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"... Here we propose that, in olfaction, a small and relatively stable set comprised of the earliest activated receptors forms a code for concentration-invariant odor identity. One prediction of this “primacy coding” scheme is that decisions based on odor identity can be made solely using early odor-evoked neural activity. Using an optogenetic masking paradigm, we define the sensory integration time necessary for odor identification and demonstrate that animals can use information occurring <100ms after inhalation onset to identify odors. ... We propose a computational model demonstrating how such a code can be read by neural circuits of the olfactory system."
Wilson CD, Serrano GO, Koulakov AA, Rinberg D (2017) A primacy code for odor identity.
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Neuron or other electrically excitable cell;
Olfactory bulb main mitral GLU cell;
Koulakov, Alexei [akula at cshl.edu];
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Olfactory bulb main mitral GLU cell
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