Model of the cerebellar granular network (Sudhakar et al 2017)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:232023
"The granular layer, which mainly consists of granule and Golgi cells, is the first stage of the cerebellar cortex and processes spatiotemporal information transmitted by mossy fiber inputs with a wide variety of firing patterns. To study its dynamics at multiple time scales in response to inputs approximating real spatiotemporal patterns, we constructed a large-scale 3D network model of the granular layer. ..."
Reference:
1 . Sudhakar SK, Hong S, Raikov I, Publio R, Lang C, Close T, Guo D, Negrello M, De Schutter E (2017) Spatiotemporal network coding of physiological mossy fiber inputs by the cerebellar granular layer. PLoS Comput Biol 13:e1005754 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum golgi cell;
Channel(s): I A; I Calcium; I K; I K,Ca; I Na,t; I h; I Na,p; I T low threshold;
Gap Junctions: Gap junctions;
Receptor(s): AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s): Glutamate; Gaba;
Simulation Environment: NEURON;
Model Concept(s): Spatio-temporal Activity Patterns; Oscillations; Synchronization; Winner-take-all;
Implementer(s): Hong, Sungho [shhong at oist.jp]; Guo, Daqing [dqguo at uestc.edu.cn]; Raikov, Ivan [ivan.g.raikov at gmail.com]; Publio, Rodrigo [publio at oist.jp]; De Schutter, Erik [erik at oist.jp];
Search NeuronDB for information about:  AMPA; NMDA; Gaba; I Na,p; I Na,t; I T low threshold; I A; I K; I h; I K,Ca; I Calcium; Gaba; Glutamate;
; -*- Hen -*-


(require-extension lalr)
(define brep-parser
  (lalr-parser

   ;; --- Options 
   ;; output a parser, called brep-parser, in a separate file - brep.yy.scm, 
   (output:    brep-parser "brep.yy.scm")
   ;; output the LALR table to brep.grm.out
   (out-table: "brep.grm.out")
   ;; there should be no conflict
   (expect:    5)

   ;; --- token definitions
   (ID NUM = LPAREN RPAREN NEWLINE COMMA STRING FUNCTION
       (left: + -)
       (left: * /)
       (nonassoc: uminus))

   ;; --- rules
   (line     (assign NEWLINE)        : $1
             (expr   NEWLINE)        : $1
	     (NEWLINE)               : #f
             (error  NEWLINE)        : #f)

   (assign   (ID = expr)             : (add-binding $1 $3))

;;   (defn   (FUNC LPAREN args RPAREN LBRACE expr RBRACE)             : (add-binding $1 $3))

   (expr     (expr + expr)           : (+ $1 $3)
             (expr - expr)           : (- $1 $3)
             (expr * expr)           : (* $1 $3)
             (expr / expr)           : (/ $1 $3)
             (- expr (prec: uminus)) : (- $2)
             (ID)                    : (get-binding $1)
             (ID LPAREN args RPAREN) : (invoke-func $1 $3)
             (NUM)                   : $1
             (LPAREN expr RPAREN)    : $2)

   (args     ()                      : '()
             (expr arg-rest)         : (cons $1 $2)
             (STRING arg-rest)       : (cons $1 $2))

   (arg-rest (COMMA expr arg-rest)   : (cons $2 $3)
             (COMMA STRING arg-rest) : (cons $2 $3)
             ()                      : '())

   ))