2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)

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Accession:232097
This is a biophysical model of the olfactory bulb (OB) that contains three types of neurons: mitral cells, granule cells and periglomerular cells. The model is used to study the cellular and synaptic mechanisms of OB gamma oscillations. We concluded that OB gamma oscillations can be best modeled by the coupled oscillator architecture termed pyramidal resonance inhibition network gamma (PRING).
Reference:
1 . Li G, Cleland TA (2017) A coupled-oscillator model of olfactory bulb gamma oscillations. PLoS Comput Biol 13:e1005760 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral cell; Olfactory bulb main interneuron granule MC cell; Olfactory bulb main interneuron periglomerular cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Olfaction;
Implementer(s): Li, Guoshi [guoshi_li at med.unc.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral cell; Olfactory bulb main interneuron periglomerular cell; Olfactory bulb main interneuron granule MC cell; GabaA; AMPA; NMDA;
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OBGAMMA
celldata
connection
data0
input
README
cadecay.mod *
cadecay2.mod *
Caint.mod *
Can.mod *
CaPN.mod *
CaT.mod *
GradeAMPA.mod *
GradeGABA.mod *
GradNMDA.mod *
hpg.mod *
kAmt.mod *
KCa.mod *
KDRmt.mod *
kfasttab.mod *
kM.mod *
KS.mod
kslowtab.mod *
LCa.mod *
nafast.mod *
NaP.mod *
Naxn.mod *
Nicotin.mod *
nmdanet.mod *
OdorInput.mod *
SineInput.mod
Background.hoc
Cal_Synch.hoc
Connect.hoc
Figure.hoc
GC_def.hoc
GC_save.hoc *
GC_Stim.hoc
Input.hoc
mathslib.hoc
MC_def.hoc
MC_save.hoc
MC_Stim.hoc
mosinit.hoc
OBNet.hoc
Parameter.hoc
PG_def.hoc
PG_save.hoc *
PG_Stim.hoc
SaveData.hoc
tabchannels.dat *
tabchannels.hoc
                            
TITLE Calcium decay
: as described in Bhalla and Bower, J. Neurophysiol. 69:1948-1983 (1993)
: Andrew Davison, The Babraham Institute, 1998
: partially based on cadecay.mod by Alain Destexhe, Salk Institute 1995.

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms) }

NEURON{
	SUFFIX cad2
	USEION ca READ ica, cai WRITE cai
	RANGE ica, channel_flow, depth, B
	GLOBAL cai, tau, cainf
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(molar) = (1/liter)
	(mM) = (millimolar)
	(um) = (micron)
}

CONSTANT {
        FARADAY = 96154 (coul)
	:FARADAY = 93149 (coul)		: moles do not appear in units
					: note this value is chosen to fit with
					: Genesis
}

PARAMETER {
	dt (ms)
	depth = 1 	(um)		: shell within which cai is calculated
					        : to match Bhalla and Bower 1993 set
					        : depth = diam/4 for each compartment
	tau = 800 	(ms)		: cai decay constant
	cainf = 1e-5	(mM)	: baseline calcium concentration
	ica		(mA/cm2)
	f = 1.0    : warmen
}

STATE {
	cai		(mM)
}

INITIAL {
	cai = cainf
}

ASSIGNED {
	channel_flow	(mM/ms)
	B		(mM cm2/ms/mA)
}

BREAKPOINT {
	SOLVE state METHOD cnexp
}

DERIVATIVE state {
	B = -f*(1e4)/(2*FARADAY*depth)
	channel_flow = B*ica
	if (channel_flow <= 0.0 ) { channel_flow = 0.0 }	: one way flow in channel
	cai' = channel_flow  - (cai - cainf)/tau
}