Knox implementation of Destexhe 1998 spike and wave oscillation model (Knox et al 2018)

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Accession:234233
" ...The aim of this study was to use an established thalamocortical computer model to determine how T-type calcium channels work in concert with cortical excitability to contribute to pathogenesis and treatment response in CAE. METHODS: The model is comprised of cortical pyramidal, cortical inhibitory, thalamocortical relay, and thalamic reticular single-compartment neurons, implemented with Hodgkin-Huxley model ion channels and connected by AMPA, GABAA , and GABAB synapses. Network behavior was simulated for different combinations of T-type calcium channel conductance, inactivation time, steady state activation/inactivation shift, and cortical GABAA conductance. RESULTS: Decreasing cortical GABAA conductance and increasing T-type calcium channel conductance converted spindle to spike and wave oscillations; smaller changes were required if both were changed in concert. In contrast, left shift of steady state voltage activation/inactivation did not lead to spike and wave oscillations, whereas right shift reduced network propensity for oscillations of any type...."
Reference:
1 . Knox AT, Glauser T, Tenney J, Lytton WW, Holland K (2018) Modeling pathogenesis and treatment response in childhood absence epilepsy. Epilepsia 59:135-145 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex; Thalamus;
Cell Type(s): Thalamus reticular nucleus GABA cell; Thalamus geniculate nucleus/lateral principal GLU cell; Hodgkin-Huxley neuron; Neocortex layer 4 pyramidal cell; Neocortex fast spiking (FS) interneuron;
Channel(s): I h; I Na,t; I K,leak; I T low threshold; I M;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Spindles; Oscillations;
Implementer(s): Knox, Andrew [knox at neurology.wisc.edu]; Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; GabaA; GabaB; AMPA; I Na,t; I T low threshold; I K,leak; I M; I h;
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KnoxEtAl2017
README.html
README_.txt
ampa.mod
cadecay.mod *
gabaa.mod
gabab.mod
HH2.mod *
Ih.mod *
IM.mod
IT.mod *
IT2.mod *
ITREcustom.mod
kleak.mod *
vecevent.mod
Fsinglecell.oc
Fspikewave.oc
membrane_potential_heat_plot.py
mosinit.hoc *
RE.tem
rundemo.hoc
screenshot1.png
screenshot2.png
screenshot3.png
sIN.tem
sPY.tem
TC.tem
                            
COMMENT
-----------------------------------------------------------------------------

  Leak potassium current
  ----------------------

  This mechanism was written to be used as a potassium channel that is
  open or closed by neuromodulators.  

  WARNING: this current is NOT inserted as a standard current, but as a 
  point process (same way as a synapse or current injection).

  Procedure for insertion:

	objectvar kl
	kl = new kleak()

	access <compartment_name>
	kl.loc(0.5)

	kl.gmax = ...



  A. Destexhe , The Salk Institute, Feb 1994.

-----------------------------------------------------------------------------
ENDCOMMENT

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

NEURON {
	POINT_PROCESS kleak
	RANGE gmax
	GLOBAL Erev
	NONSPECIFIC_CURRENT i
}
UNITS {
	(nA) = (nanoamp)
	(mV) = (millivolt)
	(umho) = (micromho)
}

PARAMETER {
	gmax	= 0.004	(umho)		: maximum conductance (microSiemens)
	Erev	= -100	(mV)		: reversal potential (potassium)
}


ASSIGNED {
	v		(mV)		: postsynaptic voltage
	i 		(nA)		: current = g*(v - Erev)
}

INITIAL {
}

BREAKPOINT {
	i = gmax * (v - Erev)
}