The afterhyperpolarization (AHP) is canonically viewed as a major factor underlying the
refractory period, serving to limit neuronal firing rate. We recently reported (Wang et al,
J. Neurophys. 116:456, 2016) that enhancing the amplitude of the fast AHP in
a relatively slowly firing neuron (versus fast spiking neurons), augments neuronal excitability
in dentate gyrus granule neurons expressing gain-of-function BK channels. Here we present a novel,
quantitative hypothesis for how varying the amplitude of the fast AHP (fAHP) can, paradoxically,
influence a subsequent spike tens of milliseconds later.
Jaffe DB, Brenner R (2018) A computational model for how the fast afterhyperpolarization paradoxically increases gain in regularly firing neurons. J Neurophysiol 119:1506-1520 [PubMed]