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Paradoxical effect of fAHP amplitude on gain in dentate gyrus granule cells (Jaffe & Brenner 2018)
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The afterhyperpolarization (AHP) is canonically viewed as a major factor underlying the refractory period, serving to limit neuronal firing rate. We recently reported (Wang et al, J. Neurophys. 116:456, 2016) that enhancing the amplitude of the fast AHP in a relatively slowly firing neuron (versus fast spiking neurons), augments neuronal excitability in dentate gyrus granule neurons expressing gain-of-function BK channels. Here we present a novel, quantitative hypothesis for how varying the amplitude of the fast AHP (fAHP) can, paradoxically, influence a subsequent spike tens of milliseconds later.
Jaffe DB, Brenner R (2018) A computational model for how the fast afterhyperpolarization paradoxically increases gain in regularly firing neurons.
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Dentate gyrus granule GLU cell;
I T low threshold;
Jaffe, David B [david.jaffe at utsa.edu];
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Dentate gyrus granule GLU cell
I T low threshold
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