Acute In vitro models have revealed a great deal of information about
mechanisms underlying many types of epileptiform activity. However,
few examples exist that shed light on spike and wave (SpW) patterns of
pathological activity. SpW are seen in many epilepsy syndromes, both
generalised and focal, and manifest across the entire age
spectrum. They are heterogeneous in terms of their severity, symptom
burden and apparent anatomical origin (thalamic, neocortical or both),
but any relationship between this heterogeneity and underlying
pathology remains elusive. Here we demonstrate that physiological
delta frequency rhythms act as an effective substrate to permit
modelling of SpW of cortical origin and may help to address this
issue.
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Reference:
1 .
Hall SP, Traub RD, Adams NE, Cunningham MO, Schofield I, Jenkins AJ, Whittington MA (2018) Enhanced interlaminar excitation or reduced superficial layer inhibition in neocortex generates different spike-and-wave-like electrographic events in vitro. J Neurophysiol 119:49-61 [PubMed]
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