Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:236310
This model achieves electrotonic transform and computes mean inward and outward attenuation from 0 to 500 Hz input; and randomly activates synapses along dendrites to simulate AMPAR mediated EPSCs. For electrotonic analysis, in Elec folder, the entry file is MSNelec_transform.hoc. For EPSC simulation, in Syn folder, the entry file is randomepsc.hoc. Run read_EPSCsims_mdb_alone.m next with the simulated parameter values specified to compute the mean EPSC.
Reference:
1 . Goodliffe JW, Song H, Rubakovic A, Chang W, Medalla M, Weaver CM, Luebke JI (2018) Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington's Disease. PLoS One 13:e0200626 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum spiny neuron;
Channel(s):
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Membrane Properties; Electrotonus; Synaptic-input statistic;
Implementer(s):
Search NeuronDB for information about:  AMPA;
/
GoodliffeEtAl2018
Elec
tau_tables
kir.mod *
actionPotentialPlayer.hoc *
all_tau_vecs.hoc
analyticFunctions.hoc *
aux_procs.hoc
baseline_values.txt
basic_procs.hoc
colorDendrites.hoc
electro_procs.hoc *
fixnseg.hoc *
load_scripts.hoc *
measureMeanAtten.hoc
MSN_fixDiams.hoc
MSNelect.hoc
MSNelect_transform.hoc
Nov3IR3a.hoc
Nov9IR2a_spine.hoc
readcell.hoc
                            

celsius = 22			// degC

global_ra = 100		// not really sure what this is
RA = 100			// ohm-cm - constant for whole cell
CM = 0.9				// uF-cm2 - constant for whole cell
G_PAS = 0.000076507			// S/cm2
E_PAS = -84.950101			// mV

G_KIR = 0.009025142		// S/cm2

EK = -94

NET_N = 1e10

G_PAS = 5.78396E-05
E_PAS =  -84.36506747
CM    = 0.9
G_KIR = 0.2
QKIR  = 0.009667857
SHKIR = 97.006722
SLPKIR = 10.555922
//dgkaf = 0.0012340247

// WTD1: Fix CM=0.966, Q_kir=0.36, shift_kir=105.84, slope=15
//{set_n_params(0.0001030188, -84.857419843, 0.0031159583) set_params() }

// WTD2: {set_n_params(0.0000297549996796, 	-60.0056740261166297, 	0.9814267106996857, 	0.0036379227189107, 	0.3407351429938239, 	88.1756405843817674, 	12.5629293010380696) set_params() }
// HETD1: {set_n_params(0.0001010765835919,    -84.9845101839923416,    0.9001067785063510,      0.0066366415746563,      0.2058273426886807,      64.2884058448628934,     4.2557075383294070) set_params() }           
// HETD2: {set_n_params(0.0000984096, -83.9580085018, 0.9496328104, 0.0011448850, 0.2013753533, 52.5428991524, 1.0012020480) set_params() } 
V0 = -80