" … Here, using computational modeling,
we show that a common biomarker of schizophrenia, namely, an increase in delta-oscillation power, may be a direct
consequence of altered expression or kinetics of voltage-gated ion channels or calcium transporters. Our model of a circuit
of layer V pyramidal cells highlights multiple types of schizophrenia-related variants that contribute to altered dynamics in
the delta frequency band. Moreover, our model predicts that the same membrane mechanisms that increase the layer V
pyramidal cell network gain and response to delta-frequency oscillations may also cause a decit in a single-cell correlate of
the prepulse inhibition, which is a behavioral biomarker highly associated with schizophrenia."
Reference:
1 .
Mäki-Marttunen T, Krull F, Bettella F, Hagen E, Næss S, Ness TV, Moberget T, Elvsåshagen T, Metzner C, Devor A, Edwards AG, Fyhn M, Djurovic S, Dale AM, Andreassen OA, Einevoll GT (2019) Alterations in Schizophrenia-Associated Genes Can Lead to Increased Power in Delta Oscillations. Cereb Cortex 29:875-891 [PubMed]
|
