"Recurrent input to sensory cortex, via long-range reciprocal projections between motor and sensory cortices, is essential
for accurate perceptual judgments. GABA levels in sensory cortices correlate with perceptual performance. We simulated
a neuron-astrocyte network model to investigate how top-down, feedback signaling from a motor network (Nmot) to a
sensory network (Nsen) affects perceptual judgments in association with ambient (extracellular) GABA levels. In the Nsen,
astrocytic transporters modulated ambient GABA levels around pyramidal cells. A simple perceptual task was implemented:
detection of a feature stimulus presented to the Nsen. ..."
Reference:
1 .
Hoshino O, Zheng M, Watanabe K (2018) Perceptual judgments via sensory-motor interaction assisted by cortical GABA. J Comput Neurosci 44:233-251 [PubMed]
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