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CA1 pyramidal neuron: Persistent Na current mediates steep synaptic amplification (Hsu et al 2018)
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This paper shows that persistent sodium current critically contributes to the subthreshold nonlinear dynamics of CA1 pyramidal neurons and promotes rapidly reversible conversion between place-cell and silent-cell in the hippocampus. A simple model built with realistic axo-somatic voltage-gated sodium channels in CA1 (Carter et al., 2012; Neuron 75, 1081–1093) demonstrates that the biophysics of persistent sodium current is sufficient to explain the synaptic amplification effects. A full model built previously (Grienberger et al., 2017; Nature Neuroscience, 20(3): 417–426) with detailed morphology, ion channel types and biophysical properties of CA1 place cells naturally reproduces the steep voltage dependence of synaptic responses.
Hsu CL, Zhao X, Milstein AD, Spruston N (2018) Persistent sodium current mediates the steep voltage dependence of spatial coding in hippocampal pyramidal neurons
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Neuron or other electrically excitable cell;
Hippocampus CA1 pyramidal GLU cell;
Abstract single compartment conductance based cell;
Ion Channel Kinetics;
Detailed Neuronal Models;
Hsu, Ching-Lung [hsuc at janelia.hhmi.org];
Milstein, Aaron D. [aaronmil at stanford.edu];
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Hippocampus CA1 pyramidal GLU cell
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043016 Type A - km2_NMDA_KIN5_Pr.pkl
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