CA1 pyramidal neuron: Persistent Na current mediates steep synaptic amplification (Hsu et al 2018)

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Accession:240960
This paper shows that persistent sodium current critically contributes to the subthreshold nonlinear dynamics of CA1 pyramidal neurons and promotes rapidly reversible conversion between place-cell and silent-cell in the hippocampus. A simple model built with realistic axo-somatic voltage-gated sodium channels in CA1 (Carter et al., 2012; Neuron 75, 1081–1093) demonstrates that the biophysics of persistent sodium current is sufficient to explain the synaptic amplification effects. A full model built previously (Grienberger et al., 2017; Nature Neuroscience, 20(3): 417–426) with detailed morphology, ion channel types and biophysical properties of CA1 place cells naturally reproduces the steep voltage dependence of synaptic responses.
Reference:
1 . Hsu CL, Zhao X, Milstein AD, Spruston N (2018) Persistent sodium current mediates the steep voltage dependence of spatial coding in hippocampal pyramidal neurons Neuron 99:1-16
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Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Channel/Receptor; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Abstract single compartment conductance based cell;
Channel(s): I Sodium; I A; I M; I h; I K;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Membrane Properties; Synaptic Integration; Synaptic Amplification; Place cell/field; Active Dendrites; Conductance distributions; Detailed Neuronal Models; Electrotonus; Markov-type model;
Implementer(s): Hsu, Ching-Lung [hsuc at janelia.hhmi.org]; Milstein, Aaron D. [aaronmil at stanford.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; NMDA; I A; I K; I M; I h; I Sodium; Glutamate;
 
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