Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:244262
"... High frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) suppresses parkinsonian motor symptoms and modulates cortical activity. ... Cortical evoked potentials (cEP) generated by STN DBS reflect the response of cortex to subcortical stimulation, and the goal was to determine the neural origin of cEP using a two-step approach. First, we recorded cEP over ipsilateral primary motor cortex during different frequencies of STN DBS in awake healthy and unilateral 6-OHDA lesioned parkinsonian rats. Second, we used a biophysically-based model of the thalamocortical network to deconstruct the neural origin of the cEP. The in vivo cEP included short (R1), intermediate (R2) and long-latency (R3) responses. Model-based cortical responses to simulated STN DBS matched remarkably well the in vivo responses. R1 was generated by antidromic activation of layer 5 pyramidal neurons, while recurrent activation of layer 5 pyramidal neurons via excitatory axon collaterals reproduced R2. R3 was generated by polysynaptic activation of layer 2/3 pyramidal neurons via the cortico-thalamic-cortical pathway. Antidromic activation of the hyperdirect pathway and subsequent intracortical and cortico-thalamo-cortical synaptic interactions were sufficient to generate cEP by STN DBS, and orthodromic activation through basal ganglia-thalamus-cortex pathways was not required. These results demonstrate the utility of cEP to determine the neural elements activated by STN DBS that might modulate cortical activity and contribute to the suppression of parkinsonian symptoms."
Reference:
1 . Kumaravelu K, Oza CS, Behrend CE, Grill WM (2018) Model-based deconstruction of cortical evoked potentials generated by subthalamic nucleus deep brain stimulation. J Neurophysiol 120:662-680 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex; Thalamus;
Cell Type(s): Neocortex M1 L6 pyramidal corticothalamic GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; Neocortex M1 L4 stellate GLU cell; Hodgkin-Huxley neuron; Neocortex layer 4 neuron; Neocortex fast spiking (FS) interneuron; Neocortex primary motor area pyramidal layer 5 corticospinal cell;
Channel(s): I Na,p; I K; I Sodium; I_KD; I Calcium; I T low threshold; I L high threshold; I_AHP;
Gap Junctions: Gap junctions;
Receptor(s): AMPA; Gaba; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Deep brain stimulation; Evoked LFP;
Implementer(s): Kumaravelu, Karthik [kk192 at duke.edu];
Search NeuronDB for information about:  Neocortex M1 L6 pyramidal corticothalamic GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; Neocortex M1 L4 stellate GLU cell; AMPA; NMDA; Gaba; I Na,p; I L high threshold; I T low threshold; I K; I Sodium; I Calcium; I_AHP; I_KD; Gaba; Glutamate;
/
cEP_stndbs_4.5hz
dat
deepaxax_v_F.dat *
deepbask_v_F.dat *
deepLTS_v_F.dat *
nointeraction.spk *
nontuftRS_v_F.dat *
nrntest.spk *
nRT_v_F.dat *
p2ctest.spk *
spinstell_v_F.dat *
supaxax_v_F.dat *
supbask_v_F.dat *
supLTS_v_F.dat *
suppyrFRB_v_F.dat *
suppyrRS_v_F.dat *
TCR_v_F.dat *
tuftIB_v_F.dat *
tuftRS_v_F.dat *
                            
    0.1000  -69.8942
    0.2000  -69.5653
    0.3000  -69.1507
    0.4000  -68.7130
    0.5000  -68.2746
    0.6000  -67.8436
    0.7000  -67.4226
    0.8000  -67.0130
    0.9000  -66.6144
    1.0000  -66.2256
    1.1000  -65.8473
    1.2000  -65.4775
    1.3000  -65.1179
    1.4000  -64.7670
    1.5000  -64.4263
    1.6000  -64.0978
    1.7000  -63.7804
    1.8000  -63.4769
    1.9000  -63.1894
    2.0000  -62.9201
    2.1000  -62.6708
    2.2000  -62.4439
    2.3000  -62.2429
    2.4000  -62.0709
    2.5000  -61.9266
    2.6000  -61.8121
    2.7000  -61.7287
    2.8000  -61.6912
    2.9000  -61.6885
    3.0000  -61.7122
    3.1000  -61.7567
    3.2000  -61.8201
    3.3000  -61.9026
    3.4000  -62.0222
    3.5000  -62.1403
    3.6000  -62.2828
    3.7000  -62.4202
    3.8000  -62.5686
    3.9000  -62.7115
    4.0000  -62.8513
    4.1000  -62.9877
    4.2000  -63.1121
    4.3000  -63.2338
    4.4000  -63.3412
    4.5000  -63.4401
    4.6000  -63.5335
    4.7000  -63.6076
    4.8000  -63.6776
    4.9000  -63.7447
    5.0000  -63.7973
    5.1000  -63.8365
    5.2000  -63.8653
    5.3000  -63.8926
    5.4000  -63.9196
    5.5000  -63.9367
    5.6000  -63.9475
    5.7000  -63.9566
    5.8000  -63.9668
    5.9000  -63.9723
    6.0000  -63.9727
    6.1000  -63.9688
    6.2000  -63.9596
    6.3000  -63.9422
    6.4000  -63.9216
    6.5000  -63.9012
    6.6000  -63.8810
    6.7000  -63.8515
    6.8000  -63.8185
    6.9000  -63.7903
    7.0000  -63.7646
    7.1000  -63.7406
    7.2000  -63.7162
    7.3000  -63.6868
    7.4000  -63.6574
    7.5000  -63.6307
    7.6000  -63.5952
    7.7000  -63.5592
    7.8000  -63.5292
    7.9000  -63.5031
    8.0000  -63.4789
    8.1000  -63.4528
    8.2000  -63.4238
    8.3000  -63.3979
    8.4000  -63.3748
    8.5000  -63.3385
    8.6000  -63.3070
    8.7000  -63.2810
    8.8000  -63.2585
    8.9000  -63.2387
    9.0000  -63.2189
    9.1000  -63.1947
    9.2000  -63.1707
    9.3000  -63.1502
    9.4000  -63.1323
    9.5000  -63.1078
    9.6000  -63.0770
    9.7000  -63.0533
    9.8000  -63.0334
    9.9000  -63.0157
   10.0000  -63.0003
   10.1000  -62.9857
   10.2000  -62.9705
   10.3000  -62.9505
   10.4000  -62.9300
   10.5000  -62.9123
   10.6000  -62.8972
   10.7000  -62.8839
   10.8000  -62.8684
   10.9000  -62.8382
   11.0000  -62.8151
   11.1000  -62.7967
   11.2000  -62.7806
   11.3000  -62.7656
   11.4000  -62.7523
   11.5000  -62.7396
   11.6000  -62.7256
   11.7000  -62.7084
   11.8000  -62.6879
   11.9000  -62.6700
   12.0000  -62.6547
   12.1000  -62.6413
   12.2000  -62.6291
   12.3000  -62.6061
   12.4000  -62.5778
   12.5000  -62.5566
   12.6000  -62.5392
   12.7000  -62.5235
   12.8000  -62.5088
   12.9000  -62.4956
   13.0000  -62.4810
   13.1000  -62.4649
   13.2000  -62.4432
   13.3000  -62.4239
   13.4000  -62.4075
   13.5000  -62.3932
   13.6000  -62.3804
   13.7000  -62.3592
   13.8000  -62.3287
   13.9000  -62.3060
   14.0000  -62.2878
   14.1000  -62.2721
   14.2000  -62.2571
   14.3000  -62.2431
   14.4000  -62.2275
   14.5000  -62.2084
   14.6000  -62.1855
   14.7000  -62.1662
   14.8000  -62.1503
   14.9000  -62.1364
   15.0000  -62.1235
   15.1000  -62.0908
   15.2000  -62.0642
   15.3000  -62.0438
   15.4000  -62.0272
   15.5000  -62.0127
   15.6000  -61.9990
   15.7000  -61.9853
   15.8000  -61.9690
   15.9000  -61.9451
   16.0000  -61.9220
   16.1000  -61.9034
   16.2000  -61.8884
   16.3000  -61.8755
   16.4000  -61.8439
   16.5000  -61.8161
   16.6000  -61.7948
   16.7000  -61.7775
   16.8000  -61.7629
   16.9000  -61.7502
   17.0000  -61.7384
   17.1000  -61.7259
   17.2000  -61.7082
   17.3000  -61.6819
   17.4000  -61.6587
   17.5000  -61.6401
   17.6000  -61.6252
   17.7000  -61.5914
   17.8000  -61.5629
   17.9000  -61.5419
   18.0000  -61.5247
   18.1000  -61.5099
   18.2000  -61.4970
   18.3000  -61.4855
   18.4000  -61.4750
   18.5000  -61.4646
   18.6000  -61.4453
   18.7000  -61.4182
   18.8000  -61.3950
   18.9000  -61.3762
   19.0000  -61.3397
   19.1000  -61.3080
   19.2000  -61.2857
   19.3000  -61.2686
   19.4000  -61.2545
   19.5000  -61.2415
   19.6000  -61.2296
   19.7000  -61.2188
   19.8000  -61.2088
   19.9000  -61.1978
   20.0000  -61.1736
   20.1000  -61.1476
   20.2000  -61.1256
   20.3000  -61.0846
   20.4000  -61.0503
   20.5000  -61.0257
   20.6000  -61.0071
   20.7000  -60.9926
   20.8000  -60.9808
   20.9000  -60.9706
   21.0000  -60.9602
   21.1000  -60.9498
   21.2000  -60.9366
   21.3000  -60.9128
   21.4000  -60.8877
   21.5000  -60.8581
   21.6000  -60.8132
   21.7000  -60.7812
   21.8000  -60.7577
   21.9000  -60.7399
   22.0000  -60.7258
   22.1000  -60.7141
   22.2000  -60.7039
   22.3000  -60.6949
   22.4000  -60.6869
   22.5000  -60.6736
   22.6000  -60.6508
   22.7000  -60.6268
   22.8000  -60.5800
   22.9000  -60.5395
   23.0000  -60.5110
   23.1000  -60.4893
   23.2000  -60.4713
   23.3000  -60.4564
   23.4000  -60.4441
   23.5000  -60.4338
   23.6000  -60.4250
   23.7000  -60.4096
   23.8000  -60.3877
   23.9000  -60.3629
   24.0000  -60.3146
   24.1000  -60.2764
   24.2000  -60.2478
   24.3000  -60.2258
   24.4000  -60.2085
   24.5000  -60.1945
   24.6000  -60.1828
   24.7000  -60.1718
   24.8000  -60.1607
   24.9000  -60.1386
   25.0000  -60.1045
   25.1000  -60.0548
   25.2000  -60.0205
   25.3000  -59.9916
   25.4000  -59.9687
   25.5000  -59.9503
   25.6000  -59.9351
   25.7000  -59.9226
   25.8000  -59.9117
   25.9000  -59.9016
   26.0000  -59.8877
   26.1000  -59.8502
   26.2000  -59.7959
   26.3000  -59.7579
   26.4000  -59.7294
   26.5000  -59.7033
   26.6000  -59.6820
   26.7000  -59.6658
   26.8000  -59.6534
   26.9000  -59.6431
   27.0000  -59.6335
   27.1000  -59.6119
   27.2000  -59.5511
   27.3000  -59.5073
   27.4000  -59.4766
   27.5000  -59.4539
   27.6000  -59.4361
   27.7000  -59.4183
   27.8000  -59.3991
   27.9000  -59.3818
   28.0000  -59.3508
   28.1000  -59.2929
   28.2000  -59.2449
   28.3000  -59.2105
   28.4000  -59.1855
   28.5000  -59.1671
   28.6000  -59.1535
   28.7000  -59.1431
   28.8000  -59.1349
   28.9000  -59.1267
   29.0000  -59.0834
   29.1000  -59.0328
   29.2000  -58.9827
   29.3000  -58.9436
   29.4000  -58.9137
   29.5000  -58.8906
   29.6000  -58.8716
   29.7000  -58.8164
   29.8000  -58.7758
   29.9000  -58.7336
   30.0000  -58.6879
   30.1000  -58.6534
   30.2000  -58.6291
   30.3000  -58.5809
   30.4000  -58.5318
   30.5000  -58.5005
   30.6000  -58.4743
   30.7000  -58.4381
   30.8000  -58.4053
   30.9000  -58.3724
   31.0000  -58.3000
   31.1000  -58.2451
   31.2000  -58.2071
   31.3000  -58.1628
   31.4000  -58.1253
   31.5000  -58.0549
   31.6000  -57.9966
   31.7000  -57.9538
   31.8000  -57.9226
   31.9000  -57.8823
   32.0000  -57.8102
   32.1000  -57.7425
   32.2000  -57.6962
   32.3000  -57.6599
   32.4000  -57.6144
   32.5000  -57.5112
   32.6000  -57.4373
   32.7000  -57.3898
   32.8000  -57.3330
   32.9000  -57.2438
   33.0000  -57.1685
   33.1000  -57.1057
   33.2000  -57.0060
   33.3000  -56.9175
   33.4000  -56.8284
   33.5000  -56.7099
   33.6000  -56.6030
   33.7000  -56.4596
   33.8000  -56.3458
   33.9000  -56.1767
   34.0000  -56.0137
   34.1000  -55.8310
   34.2000  -55.6127
   34.3000  -55.3648
   34.4000  -55.0663
   34.5000  -54.7010
   34.6000  -54.2493
   34.7000  -53.6542
   34.8000  -52.8291
   34.9000  -51.5572
   35.0000  -49.2675
   35.1000  -43.4619
   35.2000  -16.9388
   35.3000   40.6630
   35.4000    4.3247
   35.5000  -20.0799
   35.6000  -44.2377
   35.7000  -68.8584
   35.8000  -68.4912
   35.9000  -64.4276
   36.0000  -60.8542
   36.1000  -58.4689
   36.2000  -58.0041
   36.3000  -58.8665
   36.4000  -60.2663
   36.5000  -61.6997
   36.6000  -62.9690
   36.7000  -64.0050
   36.8000  -64.7961
   36.9000  -65.3637
   37.0000  -65.7463
   37.1000  -65.9866
   37.2000  -66.1177
   37.3000  -66.1740
   37.4000  -66.1739
   37.5000  -66.1324
   37.6000  -66.0601
   37.7000  -65.9749
   37.8000  -65.8834
   37.9000  -65.7839
   38.0000  -65.6872
   38.1000  -65.5918
   38.2000  -65.4967
   38.3000  -65.4098
   38.4000  -65.3239
   38.5000  -65.2422
   38.6000  -65.1690
   38.7000  -65.0968
   38.8000  -65.0241
   38.9000  -64.9612
   39.0000  -64.9013
   39.1000  -64.8384
   39.2000  -64.7762
   39.3000  -64.7229
   39.4000  -64.6741
   39.5000  -64.6231
   39.6000  -64.5647
   39.7000  -64.5137
   39.8000  -64.4699
   39.9000  -64.4304
   40.0000  -64.3872
   40.1000  -64.3383
   40.2000  -64.2909
   40.3000  -64.2518
   40.4000  -64.2180
   40.5000  -64.1882
   40.6000  -64.1552
   40.7000  -64.1209
   40.8000  -64.0776
   40.9000  -64.0425
   41.0000  -64.0145
   41.1000  -63.9911
   41.2000  -63.9707
   41.3000  -63.9528
   41.4000  -63.9370
   41.5000  -63.9183
   41.6000  -63.8975
   41.7000  -63.8782
   41.8000  -63.8513
   41.9000  -63.8263
   42.0000  -63.8085
   42.1000  -63.7954
   42.2000  -63.7856
   42.3000  -63.7780
   42.4000  -63.7721
   42.5000  -63.7673
   42.6000  -63.7632
   42.7000  -63.7597
   42.8000  -63.7565
   42.9000  -63.7537
   43.0000  -63.7510
   43.1000  -63.7485
   43.2000  -63.7462
   43.3000  -63.7439
   43.4000  -63.7416
   43.5000  -63.7395
   43.6000  -63.7373
   43.7000  -63.7349
   43.8000  -63.7326
   43.9000  -63.7304
   44.0000  -63.7285
   44.1000  -63.7269
   44.2000  -63.7255
   44.3000  -63.7241
   44.4000  -63.7225
   44.5000  -63.7208
   44.6000  -63.7195
   44.7000  -63.7185
   44.8000  -63.7179
   44.9000  -63.7175
   45.0000  -63.7173
   45.1000  -63.7172
   45.2000  -63.7173
   45.3000  -63.7175
   45.4000  -63.7177
   45.5000  -63.7180
   45.6000  -63.7184
   45.7000  -63.7187
   45.8000  -63.7191
   45.9000  -63.7195
   46.0000  -63.7198
   46.1000  -63.7202
   46.2000  -63.7205
   46.3000  -63.7208
   46.4000  -63.7211
   46.5000  -63.7214
   46.6000  -63.7217
   46.7000  -63.7219
   46.8000  -63.7221
   46.9000  -63.7223
   47.0000  -63.7224
   47.1000  -63.7226
   47.2000  -63.7227
   47.3000  -63.7227
   47.4000  -63.7228
   47.5000  -63.7228
   47.6000  -63.7228
   47.7000  -63.7227
   47.8000  -63.7226
   47.9000  -63.7225
   48.0000  -63.7224
   48.1000  -63.7222
   48.2000  -63.7221
   48.3000  -63.7218
   48.4000  -63.7216
   48.5000  -63.7213
   48.6000  -63.7210
   48.7000  -63.7206
   48.8000  -63.7201
   48.9000  -63.7196
   49.0000  -63.7191
   49.1000  -63.7185
   49.2000  -63.7179
   49.3000  -63.7173
   49.4000  -63.7167
   49.5000  -63.7162
   49.6000  -63.7156
   49.7000  -63.7150
   49.8000  -63.7143
   49.9000  -63.7137