Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:244262
"... High frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) suppresses parkinsonian motor symptoms and modulates cortical activity. ... Cortical evoked potentials (cEP) generated by STN DBS reflect the response of cortex to subcortical stimulation, and the goal was to determine the neural origin of cEP using a two-step approach. First, we recorded cEP over ipsilateral primary motor cortex during different frequencies of STN DBS in awake healthy and unilateral 6-OHDA lesioned parkinsonian rats. Second, we used a biophysically-based model of the thalamocortical network to deconstruct the neural origin of the cEP. The in vivo cEP included short (R1), intermediate (R2) and long-latency (R3) responses. Model-based cortical responses to simulated STN DBS matched remarkably well the in vivo responses. R1 was generated by antidromic activation of layer 5 pyramidal neurons, while recurrent activation of layer 5 pyramidal neurons via excitatory axon collaterals reproduced R2. R3 was generated by polysynaptic activation of layer 2/3 pyramidal neurons via the cortico-thalamic-cortical pathway. Antidromic activation of the hyperdirect pathway and subsequent intracortical and cortico-thalamo-cortical synaptic interactions were sufficient to generate cEP by STN DBS, and orthodromic activation through basal ganglia-thalamus-cortex pathways was not required. These results demonstrate the utility of cEP to determine the neural elements activated by STN DBS that might modulate cortical activity and contribute to the suppression of parkinsonian symptoms."
Reference:
1 . Kumaravelu K, Oza CS, Behrend CE, Grill WM (2018) Model-based deconstruction of cortical evoked potentials generated by subthalamic nucleus deep brain stimulation. J Neurophysiol 120:662-680 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex; Thalamus;
Cell Type(s): Neocortex M1 L6 pyramidal corticothalamic GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; Neocortex M1 L4 stellate GLU cell; Hodgkin-Huxley neuron; Neocortex layer 4 neuron; Neocortex fast spiking (FS) interneuron; Neocortex primary motor area pyramidal layer 5 corticospinal cell;
Channel(s): I Na,p; I K; I Sodium; I_KD; I Calcium; I T low threshold; I L high threshold; I_AHP;
Gap Junctions: Gap junctions;
Receptor(s): AMPA; Gaba; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Deep brain stimulation; Evoked LFP;
Implementer(s): Kumaravelu, Karthik [kk192 at duke.edu];
Search NeuronDB for information about:  Neocortex M1 L6 pyramidal corticothalamic GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; Neocortex M1 L4 stellate GLU cell; AMPA; NMDA; Gaba; I Na,p; I L high threshold; I T low threshold; I K; I Sodium; I Calcium; I_AHP; I_KD; Gaba; Glutamate;
/
cEP_stndbs_4.5hz
dat
deepaxax_v_F.dat *
deepbask_v_F.dat *
deepLTS_v_F.dat *
nointeraction.spk *
nontuftRS_v_F.dat *
nrntest.spk *
nRT_v_F.dat *
p2ctest.spk *
spinstell_v_F.dat *
supaxax_v_F.dat *
supbask_v_F.dat *
supLTS_v_F.dat *
suppyrFRB_v_F.dat *
suppyrRS_v_F.dat *
TCR_v_F.dat *
tuftIB_v_F.dat *
tuftRS_v_F.dat *
                            
    0.1000  -64.6585
    0.2000  -64.0741
    0.3000  -63.3925
    0.4000  -62.6366
    0.5000  -61.7985
    0.6000  -60.8452
    0.7000  -59.7048
    0.8000  -58.2369
    0.9000  -56.0639
    1.0000  -51.7423
    1.1000  -30.7222
    1.2000   47.7937
    1.3000   27.7379
    1.4000    0.9343
    1.5000  -17.2945
    1.6000  -38.9103
    1.7000  -84.9868
    1.8000  -86.4820
    1.9000  -82.3005
    2.0000  -77.7318
    2.1000  -74.5424
    2.2000  -72.4055
    2.3000  -70.9368
    2.4000  -69.8485
    2.5000  -68.9517
    2.6000  -68.1508
    2.7000  -67.4012
    2.8000  -66.6843
    2.9000  -65.9948
    3.0000  -65.3323
    3.1000  -64.6974
    3.2000  -64.0909
    3.3000  -63.5094
    3.4000  -62.9504
    3.5000  -62.4087
    3.6000  -61.8795
    3.7000  -61.3537
    3.8000  -60.8202
    3.9000  -60.2669
    4.0000  -59.6770
    4.1000  -59.0273
    4.2000  -58.2699
    4.3000  -57.3320
    4.4000  -56.0557
    4.5000  -54.0144
    4.6000  -49.4511
    4.7000  -25.4389
    4.8000   46.5761
    4.9000   22.5153
    5.0000   -3.0167
    5.1000  -21.5420
    5.2000  -48.9458
    5.3000  -83.0944
    5.4000  -82.8482
    5.5000  -77.6734
    5.6000  -73.0882
    5.7000  -69.5231
    5.8000  -67.6628
    5.9000  -66.8892
    6.0000  -66.6376
    6.1000  -66.5780
    6.2000  -66.5136
    6.3000  -66.3684
    6.4000  -66.1243
    6.5000  -65.8040
    6.6000  -65.4325
    6.7000  -65.0342
    6.8000  -64.6257
    6.9000  -64.2183
    7.0000  -63.8223
    7.1000  -63.4376
    7.2000  -63.0708
    7.3000  -62.7167
    7.4000  -62.3794
    7.5000  -62.0528
    7.6000  -61.7357
    7.7000  -61.4274
    7.8000  -61.1258
    7.9000  -60.8252
    8.0000  -60.5196
    8.1000  -60.2065
    8.2000  -59.8855
    8.3000  -59.5435
    8.4000  -59.1709
    8.5000  -58.7581
    8.6000  -58.2814
    8.7000  -57.7084
    8.8000  -56.9859
    8.9000  -56.0000
    9.0000  -54.4764
    9.1000  -51.5116
    9.2000  -41.0403
    9.3000   39.6563
    9.4000   35.6148
    9.5000    5.0177
    9.6000  -14.2628
    9.7000  -33.9388
    9.8000  -77.4499
    9.9000  -83.5135
   10.0000  -79.2992
   10.1000  -74.4784
   10.2000  -70.4935
   10.3000  -67.9548
   10.4000  -66.8649
   10.5000  -66.4768
   10.6000  -66.4086
   10.7000  -66.4045
   10.8000  -66.3271
   10.9000  -66.1437
   11.0000  -65.8686
   11.1000  -65.5269
   11.2000  -65.1472
   11.3000  -64.7511
   11.4000  -64.3562
   11.5000  -63.9697
   11.6000  -63.6032
   11.7000  -63.2544
   11.8000  -62.9288
   11.9000  -62.6264
   12.0000  -62.3448
   12.1000  -62.0823
   12.2000  -61.8391
   12.3000  -61.6116
   12.4000  -61.3985
   12.5000  -61.1985
   12.6000  -61.0116
   12.7000  -60.8495
   12.8000  -60.6744
   12.9000  -60.5203
   13.0000  -60.3798
   13.1000  -60.2323
   13.2000  -60.1074
   13.3000  -59.9649
   13.4000  -59.8619
   13.5000  -59.7204
   13.6000  -59.6268
   13.7000  -59.4911
   13.8000  -59.3935
   13.9000  -59.2832
   14.0000  -59.1702
   14.1000  -59.0640
   14.2000  -58.9513
   14.3000  -58.8580
   14.4000  -58.7206
   14.5000  -58.6241
   14.6000  -58.4714
   14.7000  -58.3650
   14.8000  -58.1917
   14.9000  -58.0356
   15.0000  -57.8583
   15.1000  -57.6394
   15.2000  -57.3886
   15.3000  -57.0852
   15.4000  -56.6949
   15.5000  -56.1913
   15.6000  -55.4876
   15.7000  -54.4132
   15.8000  -52.4991
   15.9000  -47.7198
   16.0000  -22.3535
   16.1000   45.3273
   16.2000   17.9953
   16.3000   -6.3817
   16.4000  -25.3085
   16.5000  -59.4232
   16.6000  -81.4237
   16.7000  -80.5754
   16.8000  -75.5319
   16.9000  -71.4379
   17.0000  -68.2197
   17.1000  -66.6026
   17.2000  -66.0558
   17.3000  -65.9824
   17.4000  -66.0820
   17.5000  -66.1552
   17.6000  -66.1201
   17.7000  -65.9561
   17.8000  -65.6999
   17.9000  -65.3813
   18.0000  -65.0282
   18.1000  -64.6647
   18.2000  -64.3079
   18.3000  -63.9655
   18.4000  -63.6473
   18.5000  -63.3556
   18.6000  -63.0905
   18.7000  -62.8538
   18.8000  -62.6415
   18.9000  -62.4518
   19.0000  -62.2951
   19.1000  -62.1582
   19.2000  -62.0379
   19.3000  -61.9477
   19.4000  -61.8812
   19.5000  -61.8065
   19.6000  -61.7591
   19.7000  -61.7371
   19.8000  -61.7324
   19.9000  -61.7393
   20.0000  -61.7541
   20.1000  -61.7749
   20.2000  -61.8040
   20.3000  -61.8366
   20.4000  -61.8779
   20.5000  -61.9633
   20.6000  -62.0332
   20.7000  -62.0950
   20.8000  -62.1733
   20.9000  -62.2652
   21.0000  -62.3383
   21.1000  -62.4190
   21.2000  -62.5161
   21.3000  -62.5916
   21.4000  -62.6701
   21.5000  -62.7641
   21.6000  -62.8391
   21.7000  -62.9108
   21.8000  -62.9966
   21.9000  -63.0691
   22.0000  -63.1284
   22.1000  -63.2048
   22.2000  -63.2744
   22.3000  -63.3341
   22.4000  -63.3848
   22.5000  -63.4509
   22.6000  -63.5062
   22.7000  -63.5587
   22.8000  -63.6030
   22.9000  -63.6484
   23.0000  -63.7009
   23.1000  -63.7411
   23.2000  -63.7819
   23.3000  -63.8188
   23.4000  -63.8513
   23.5000  -63.8799
   23.6000  -63.9267
   23.7000  -63.9605
   23.8000  -63.9870
   23.9000  -64.0166
   24.0000  -64.0438
   24.1000  -64.0665
   24.2000  -64.0882
   24.3000  -64.1078
   24.4000  -64.1246
   24.5000  -64.1604
   24.6000  -64.1880
   24.7000  -64.2090
   24.8000  -64.2259
   24.9000  -64.2399
   25.0000  -64.2587
   25.1000  -64.2778
   25.2000  -64.2937
   25.3000  -64.3069
   25.4000  -64.3178
   25.5000  -64.3278
   25.6000  -64.3386
   25.7000  -64.3489
   25.8000  -64.3584
   25.9000  -64.3668
   26.0000  -64.3742
   26.1000  -64.3995
   26.2000  -64.4203
   26.3000  -64.4353
   26.4000  -64.4471
   26.5000  -64.4567
   26.6000  -64.4645
   26.7000  -64.4709
   26.8000  -64.4762
   26.9000  -64.4807
   27.0000  -64.4845
   27.1000  -64.4878
   27.2000  -64.4907
   27.3000  -64.4951
   27.4000  -64.5061
   27.5000  -64.5162
   27.6000  -64.5242
   27.7000  -64.5305
   27.8000  -64.5355
   27.9000  -64.5395
   28.0000  -64.5427
   28.1000  -64.5453
   28.2000  -64.5475
   28.3000  -64.5493
   28.4000  -64.5508
   28.5000  -64.5521
   28.6000  -64.5532
   28.7000  -64.5541
   28.8000  -64.5548
   28.9000  -64.5554
   29.0000  -64.5559
   29.1000  -64.5563
   29.2000  -64.5566
   29.3000  -64.5568
   29.4000  -64.5569
   29.5000  -64.5568
   29.6000  -64.5567
   29.7000  -64.5566
   29.8000  -64.5563
   29.9000  -64.5560
   30.0000  -64.5556
   30.1000  -64.5551
   30.2000  -64.5545
   30.3000  -64.5539
   30.4000  -64.5532
   30.5000  -64.5524
   30.6000  -64.5515
   30.7000  -64.5506
   30.8000  -64.5496
   30.9000  -64.5485
   31.0000  -64.5473
   31.1000  -64.5461
   31.2000  -64.5448
   31.3000  -64.5434
   31.4000  -64.5419
   31.5000  -64.5404
   31.6000  -64.5389
   31.7000  -64.5373
   31.8000  -64.5356
   31.9000  -64.5338
   32.0000  -64.5321
   32.1000  -64.5302
   32.2000  -64.5283
   32.3000  -64.5263
   32.4000  -64.5243
   32.5000  -64.5223
   32.6000  -64.5201
   32.7000  -64.5180
   32.8000  -64.5158
   32.9000  -64.5135
   33.0000  -64.5112
   33.1000  -64.5088
   33.2000  -64.5064
   33.3000  -64.5040
   33.4000  -64.5015
   33.5000  -64.4989
   33.6000  -64.4963
   33.7000  -64.4935
   33.8000  -64.4886
   33.9000  -64.4768
   34.0000  -64.4660
   34.1000  -64.4572
   34.2000  -64.4499
   34.3000  -64.4438
   34.4000  -64.4385
   34.5000  -64.4340
   34.6000  -64.4299
   34.7000  -64.4261
   34.8000  -64.4226
   34.9000  -64.4193
   35.0000  -64.4161
   35.1000  -64.4132
   35.2000  -64.4104
   35.3000  -64.4077
   35.4000  -64.4045
   35.5000  -64.4011
   35.6000  -64.3979
   35.7000  -64.3949
   35.8000  -64.3919
   35.9000  -64.3891
   36.0000  -64.3863
   36.1000  -64.3835
   36.2000  -64.3808
   36.3000  -64.3782
   36.4000  -64.3756
   36.5000  -64.3560
   36.6000  -64.3372
   36.7000  -64.3223
   36.8000  -64.3093
   36.9000  -64.2988
   37.0000  -64.2902
   37.1000  -64.2832
   37.2000  -64.2773
   37.3000  -64.2722
   37.4000  -64.2677
   37.5000  -64.2636
   37.6000  -64.2599
   37.7000  -64.2564
   37.8000  -64.2530
   37.9000  -64.2498
   38.0000  -64.2466
   38.1000  -64.2435
   38.2000  -64.2403
   38.3000  -64.2337
   38.4000  -64.2208
   38.5000  -64.2094
   38.6000  -64.2001
   38.7000  -64.1925
   38.8000  -64.1860
   38.9000  -64.1805
   39.0000  -64.1757
   39.1000  -64.1713
   39.2000  -64.1673
   39.3000  -64.1636
   39.4000  -64.1601
   39.5000  -64.1569
   39.6000  -64.1539
   39.7000  -64.1506
   39.8000  -64.1470
   39.9000  -64.1435
   40.0000  -64.1402
   40.1000  -64.1370
   40.2000  -64.1340
   40.3000  -64.1310
   40.4000  -64.1282
   40.5000  -64.1254
   40.6000  -64.1029
   40.7000  -64.0839
   40.8000  -64.0694
   40.9000  -64.0561
   41.0000  -64.0450
   41.1000  -64.0361
   41.2000  -64.0288
   41.3000  -64.0227
   41.4000  -64.0175
   41.5000  -64.0130
   41.6000  -64.0090
   41.7000  -64.0054
   41.8000  -64.0020
   41.9000  -63.9987
   42.0000  -63.9956
   42.1000  -63.9926
   42.2000  -63.9897
   42.3000  -63.9868
   42.4000  -63.9810
   42.5000  -63.9678
   42.6000  -63.9559
   42.7000  -63.9462
   42.8000  -63.9383
   42.9000  -63.9318
   43.0000  -63.9263
   43.1000  -63.9215
   43.2000  -63.9173
   43.3000  -63.9136
   43.4000  -63.9101
   43.5000  -63.9068
   43.6000  -63.9037
   43.7000  -63.9008
   43.8000  -63.8981
   43.9000  -63.8955
   44.0000  -63.8931
   44.1000  -63.8906
   44.2000  -63.8874
   44.3000  -63.8843
   44.4000  -63.8814
   44.5000  -63.8786
   44.6000  -63.8759
   44.7000  -63.8578
   44.8000  -63.8359
   44.9000  -63.8213
   45.0000  -63.8097
   45.1000  -63.7980
   45.2000  -63.7879
   45.3000  -63.7796
   45.4000  -63.7730
   45.5000  -63.7675
   45.6000  -63.7628
   45.7000  -63.7588
   45.8000  -63.7553
   45.9000  -63.7521
   46.0000  -63.7492
   46.1000  -63.7465
   46.2000  -63.7439
   46.3000  -63.7414
   46.4000  -63.7389
   46.5000  -63.7365
   46.6000  -63.7341
   46.7000  -63.7317
   46.8000  -63.7259
   46.9000  -63.7128
   47.0000  -63.7011
   47.1000  -63.6916
   47.2000  -63.6838
   47.3000  -63.6772
   47.4000  -63.6717
   47.5000  -63.6670
   47.6000  -63.6630
   47.7000  -63.6594
   47.8000  -63.6562
   47.9000  -63.6532
   48.0000  -63.6505
   48.1000  -63.6479
   48.2000  -63.6454
   48.3000  -63.6430
   48.4000  -63.6407
   48.5000  -63.6383
   48.6000  -63.6361
   48.7000  -63.6340
   48.8000  -63.6321
   48.9000  -63.6303
   49.0000  -63.6286
   49.1000  -63.6269
   49.2000  -63.6250
   49.3000  -63.5982
   49.4000  -63.5783
   49.5000  -63.5644
   49.6000  -63.5540
   49.7000  -63.5456
   49.8000  -63.5362
   49.9000  -63.5276