Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)

 Download zip file 
Help downloading and running models
Accession:245411
We use a computational model of a striatal spiny projection neuron to investigate dendritic spine calcium dynamics in response to spatiotemporal patterns of synaptic inputs. We show that spine calcium elevation is stimulus-specific, with supralinear calcium elevation in cooperatively stimulated spines. Intermediate calcium elevation occurs in neighboring non-stimulated dendritic spines, predicting heterosynaptic effects. Inhibitory synaptic inputs enhance the difference between peak calcium in stimulated spines, and peak calcium in non-stimulated spines, thereby enhancing stimulus specificity.
Reference:
1 . Dorman DB, Jedrzejewska-Szmek J, Blackwell KT (2018) Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model. Elife, Kennedy, Mary B, ed. [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): Ca pump; Kir; I A; I A, slow; I CAN; I K,Ca; I Krp; I Na,t; I L high threshold; I R; I T low threshold; IK Bkca; IK Skca; Na/Ca exchanger;
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s): Cav3.2 CACNA1H; Cav3.3 CACNA1I; Cav1.2 CACNA1C; Cav1.3 CACNA1D; Cav2.2 CACNA1B; Kv4.2 KCND2; Kir2.1 KCNJ2; Kv2.1 KCNB1;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Calcium dynamics; Detailed Neuronal Models; Synaptic Integration; Synaptic Plasticity;
Implementer(s): Dorman, Daniel B ;
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K,Ca; I CAN; I A, slow; Na/Ca exchanger; I Krp; I R; Ca pump; Kir; IK Bkca; IK Skca; Gaba; Glutamate;
//***************************		MS Model, Version 5.0	**********************  
//*************************** 	 MScell.p 			**********************  
//			Tom Sheehan tsheeha2@gmu.edu	thsheeha@vt.edu	703-538-836   
//*****************************************************************************     
     
*relative     
*cartesian     
*asymmetric     
*lambda_warn     
     
//RM, RA, CM set in globals
     
*start_cell     
*cylindrical     
soma none 11.3137 0 0 22.6274
     
primdend1 soma 12 0 0 2.25
primdend2 soma 12 0 0 2.25
primdend3 soma 12 0 0 2.25
primdend4 soma 12 0 0 2.25
     
secdend11 primdend1 14 0 0 1.417
secdend12 primdend1 14 0 0 1.417
secdend21 primdend2 14 0 0 1.417
secdend22 primdend2 14 0 0 1.417
secdend31 primdend3 14 0 0 1.417
secdend32 primdend3 14 0 0 1.417
secdend41 primdend4 14 0 0 1.417
secdend42 primdend4 14 0 0 1.417
     
tertdend1_1 secdend11 9 0 0 0.893
tertdend1_1_2 . 9 0 0 0.893
tertdend1_2 . 9 0 0 0.834
tertdend1_2_2 . 9 0 0 0.834
tertdend1_3 . 9 0 0 0.774
tertdend1_3_2 . 9 0 0 0.774
tertdend1_4 . 9 0 0 0.715
tertdend1_4_2 . 9 0 0 0.715
tertdend1_5 . 9 0 0 0.656
tertdend1_5_2 . 9 0 0 0.656
tertdend1_6 . 9 0 0 0.597
tertdend1_6_2 . 9 0 0 0.597
tertdend1_7 . 9 0 0 0.537
tertdend1_7_2 . 9 0 0 0.537
tertdend1_8 . 9 0 0 0.478
tertdend1_8_2 . 9 0 0 0.478
tertdend1_9 . 9 0 0 0.419
tertdend1_9_2 . 9 0 0 0.419
tertdend1_10 . 9 0 0 0.359
tertdend1_10_2 . 9 0 0 0.359
tertdend1_11 . 9 0 0 0.3
tertdend1_11_2 . 9 0 0 0.3
     
tertdend2_1 secdend11 9 0 0 0.893
tertdend2_1_2 . 9 0 0 0.893
tertdend2_2 . 9 0 0 0.834
tertdend2_2_2 . 9 0 0 0.834
tertdend2_3 . 9 0 0 0.774
tertdend2_3_2 . 9 0 0 0.774
tertdend2_4 . 9 0 0 0.715
tertdend2_4_2 . 9 0 0 0.715
tertdend2_5 . 9 0 0 0.656
tertdend2_5_2 . 9 0 0 0.656
tertdend2_6 . 9 0 0 0.597
tertdend2_6_2 . 9 0 0 0.597
tertdend2_7 . 9 0 0 0.537
tertdend2_7_2 . 9 0 0 0.537
tertdend2_8 . 9 0 0 0.478
tertdend2_8_2 . 9 0 0 0.478
tertdend2_9 . 9 0 0 0.419
tertdend2_9_2 . 9 0 0 0.419
tertdend2_10 . 9 0 0 0.359
tertdend2_10_2 . 9 0 0 0.359
tertdend2_11 . 9 0 0 0.3
tertdend2_11_2 . 9 0 0 0.3
     
tertdend3_1 secdend12 9 0 0 0.893
tertdend3_1_2 . 9 0 0 0.893
tertdend3_2 . 9 0 0 0.834
tertdend3_2_2 . 9 0 0 0.834
tertdend3_3 . 9 0 0 0.774
tertdend3_3_2 . 9 0 0 0.774
tertdend3_4 . 9 0 0 0.715
tertdend3_4_2 . 9 0 0 0.715
tertdend3_5 . 9 0 0 0.656
tertdend3_5_2 . 9 0 0 0.656
tertdend3_6 . 9 0 0 0.597
tertdend3_6_2 . 9 0 0 0.597
tertdend3_7 . 9 0 0 0.537
tertdend3_7_2 . 9 0 0 0.537
tertdend3_8 . 9 0 0 0.478
tertdend3_8_2 . 9 0 0 0.478
tertdend3_9 . 9 0 0 0.419
tertdend3_9_2 . 9 0 0 0.419
tertdend3_10 . 9 0 0 0.359
tertdend3_10_2 . 9 0 0 0.359
tertdend3_11 . 9 0 0 0.3
tertdend3_11_2 . 9 0 0 0.3
     
tertdend4_1 secdend12 9 0 0 0.893
tertdend4_1_2 . 9 0 0 0.893
tertdend4_2 . 9 0 0 0.834
tertdend4_2_2 . 9 0 0 0.834
tertdend4_3 . 9 0 0 0.774
tertdend4_3_2 . 9 0 0 0.774
tertdend4_4 . 9 0 0 0.715
tertdend4_4_2 . 9 0 0 0.715
tertdend4_5 . 9 0 0 0.656
tertdend4_5_2 . 9 0 0 0.656
tertdend4_6 . 9 0 0 0.597
tertdend4_6_2 . 9 0 0 0.597
tertdend4_7 . 9 0 0 0.537
tertdend4_7_2 . 9 0 0 0.537
tertdend4_8 . 9 0 0 0.478
tertdend4_8_2 . 9 0 0 0.478
tertdend4_9 . 9 0 0 0.419
tertdend4_9_2 . 9 0 0 0.419
tertdend4_10 . 9 0 0 0.359
tertdend4_10_2 . 9 0 0 0.359
tertdend4_11 . 9 0 0 0.3
tertdend4_11_2 . 9 0 0 0.3
     
tertdend5_1 secdend21 9 0 0 0.893
tertdend5_1_2 . 9 0 0 0.893
tertdend5_2 . 9 0 0 0.834
tertdend5_2_2 . 9 0 0 0.834
tertdend5_3 . 9 0 0 0.774
tertdend5_3_2 . 9 0 0 0.774
tertdend5_4 . 9 0 0 0.715
tertdend5_4_2 . 9 0 0 0.715
tertdend5_5 . 9 0 0 0.656
tertdend5_5_2 . 9 0 0 0.656
tertdend5_6 . 9 0 0 0.597
tertdend5_6_2 . 9 0 0 0.597
tertdend5_7 . 9 0 0 0.537
tertdend5_7_2 . 9 0 0 0.537
tertdend5_8 . 9 0 0 0.478
tertdend5_8_2 . 9 0 0 0.478
tertdend5_9 . 9 0 0 0.419
tertdend5_9_2 . 9 0 0 0.419
tertdend5_10 . 9 0 0 0.359
tertdend5_10_2 . 9 0 0 0.359
tertdend5_11 . 9 0 0 0.3
tertdend5_11_2 . 9 0 0 0.3
     
tertdend6_1 secdend21 9 0 0 0.893
tertdend6_1_2 . 9 0 0 0.893
tertdend6_2 . 9 0 0 0.834
tertdend6_2_2 . 9 0 0 0.834
tertdend6_3 . 9 0 0 0.774
tertdend6_3_2 . 9 0 0 0.774
tertdend6_4 . 9 0 0 0.715
tertdend6_4_2 . 9 0 0 0.715
tertdend6_5 . 9 0 0 0.656
tertdend6_5_2 . 9 0 0 0.656
tertdend6_6 . 9 0 0 0.597
tertdend6_6_2 . 9 0 0 0.597
tertdend6_7 . 9 0 0 0.537
tertdend6_7_2 . 9 0 0 0.537
tertdend6_8 . 9 0 0 0.478
tertdend6_8_2 . 9 0 0 0.478
tertdend6_9 . 9 0 0 0.419
tertdend6_9_2 . 9 0 0 0.419
tertdend6_10 . 9 0 0 0.359
tertdend6_10_2 . 9 0 0 0.359
tertdend6_11 . 9 0 0 0.3
tertdend6_11_2 . 9 0 0 0.3
     
tertdend7_1 secdend22 9 0 0 0.893
tertdend7_1_2 . 9 0 0 0.893
tertdend7_2 . 9 0 0 0.834
tertdend7_2_2 . 9 0 0 0.834
tertdend7_3 . 9 0 0 0.774
tertdend7_3_2 . 9 0 0 0.774
tertdend7_4 . 9 0 0 0.715
tertdend7_4_2 . 9 0 0 0.715
tertdend7_5 . 9 0 0 0.656
tertdend7_5_2 . 9 0 0 0.656
tertdend7_6 . 9 0 0 0.597
tertdend7_6_2 . 9 0 0 0.597
tertdend7_7 . 9 0 0 0.537
tertdend7_7_2 . 9 0 0 0.537
tertdend7_8 . 9 0 0 0.478
tertdend7_8_2 . 9 0 0 0.478
tertdend7_9 . 9 0 0 0.419
tertdend7_9_2 . 9 0 0 0.419
tertdend7_10 . 9 0 0 0.359
tertdend7_10_2 . 9 0 0 0.359
tertdend7_11 . 9 0 0 0.3
tertdend7_11_2 . 9 0 0 0.3
     
tertdend8_1 secdend22 9 0 0 0.893
tertdend8_1_2 . 9 0 0 0.893
tertdend8_2 . 9 0 0 0.834
tertdend8_2_2 . 9 0 0 0.834
tertdend8_3 . 9 0 0 0.774
tertdend8_3_2 . 9 0 0 0.774
tertdend8_4 . 9 0 0 0.715
tertdend8_4_2 . 9 0 0 0.715
tertdend8_5 . 9 0 0 0.656
tertdend8_5_2 . 9 0 0 0.656
tertdend8_6 . 9 0 0 0.597
tertdend8_6_2 . 9 0 0 0.597
tertdend8_7 . 9 0 0 0.537
tertdend8_7_2 . 9 0 0 0.537
tertdend8_8 . 9 0 0 0.478
tertdend8_8_2 . 9 0 0 0.478
tertdend8_9 . 9 0 0 0.419
tertdend8_9_2 . 9 0 0 0.419
tertdend8_10 . 9 0 0 0.359
tertdend8_10_2 . 9 0 0 0.359
tertdend8_11 . 9 0 0 0.3
tertdend8_11_2 . 9 0 0 0.3
     
tertdend9_1 secdend31 9 0 0 0.893
tertdend9_1_2 . 9 0 0 0.893
tertdend9_2 . 9 0 0 0.834
tertdend9_2_2 . 9 0 0 0.834
tertdend9_3 . 9 0 0 0.774
tertdend9_3_2 . 9 0 0 0.774
tertdend9_4 . 9 0 0 0.715
tertdend9_4_2 . 9 0 0 0.715
tertdend9_5 . 9 0 0 0.656
tertdend9_5_2 . 9 0 0 0.656
tertdend9_6 . 9 0 0 0.597
tertdend9_6_2 . 9 0 0 0.597
tertdend9_7 . 9 0 0 0.537
tertdend9_7_2 . 9 0 0 0.537
tertdend9_8 . 9 0 0 0.478
tertdend9_8_2 . 9 0 0 0.478
tertdend9_9 . 9 0 0 0.419
tertdend9_9_2 . 9 0 0 0.419
tertdend9_10 . 9 0 0 0.359
tertdend9_10_2 . 9 0 0 0.359
tertdend9_11 . 9 0 0 0.3
tertdend9_11_2 . 9 0 0 0.3
     
tertdend10_1 secdend31 9 0 0 0.893
tertdend10_1_2 . 9 0 0 0.893
tertdend10_2 . 9 0 0 0.834
tertdend10_2_2 . 9 0 0 0.834
tertdend10_3 . 9 0 0 0.774
tertdend10_3_2 . 9 0 0 0.774
tertdend10_4 . 9 0 0 0.715
tertdend10_4_2 . 9 0 0 0.715
tertdend10_5 . 9 0 0 0.656
tertdend10_5_2 . 9 0 0 0.656
tertdend10_6 . 9 0 0 0.597
tertdend10_6_2 . 9 0 0 0.597
tertdend10_7 . 9 0 0 0.537
tertdend10_7_2 . 9 0 0 0.537
tertdend10_8 . 9 0 0 0.478
tertdend10_8_2 . 9 0 0 0.478
tertdend10_9 . 9 0 0 0.419
tertdend10_9_2 . 9 0 0 0.419
tertdend10_10 . 9 0 0 0.359
tertdend10_10_2 . 9 0 0 0.359
tertdend10_11 . 9 0 0 0.3
tertdend10_11_2 . 9 0 0 0.3
     
tertdend11_1 secdend32 9 0 0 0.893
tertdend11_1_2 . 9 0 0 0.893
tertdend11_2 . 9 0 0 0.834
tertdend11_2_2 . 9 0 0 0.834
tertdend11_3 . 9 0 0 0.774
tertdend11_3_2 . 9 0 0 0.774
tertdend11_4 . 9 0 0 0.715
tertdend11_4_2 . 9 0 0 0.715
tertdend11_5 . 9 0 0 0.656
tertdend11_5_2 . 9 0 0 0.656
tertdend11_6 . 9 0 0 0.597
tertdend11_6_2 . 9 0 0 0.597
tertdend11_7 . 9 0 0 0.537
tertdend11_7_2 . 9 0 0 0.537
tertdend11_8 . 9 0 0 0.478
tertdend11_8_2 . 9 0 0 0.478
tertdend11_9 . 9 0 0 0.419
tertdend11_9_2 . 9 0 0 0.419
tertdend11_10 . 9 0 0 0.359
tertdend11_10_2 . 9 0 0 0.359
tertdend11_11 . 9 0 0 0.3
tertdend11_11_2 . 9 0 0 0.3
     
tertdend12_1 secdend32 9 0 0 0.893
tertdend12_1_2 . 9 0 0 0.893
tertdend12_2 . 9 0 0 0.834
tertdend12_2_2 . 9 0 0 0.834
tertdend12_3 . 9 0 0 0.774
tertdend12_3_2 . 9 0 0 0.774
tertdend12_4 . 9 0 0 0.715
tertdend12_4_2 . 9 0 0 0.715
tertdend12_5 . 9 0 0 0.656
tertdend12_5_2 . 9 0 0 0.656
tertdend12_6 . 9 0 0 0.597
tertdend12_6_2 . 9 0 0 0.597
tertdend12_7 . 9 0 0 0.537
tertdend12_7_2 . 9 0 0 0.537
tertdend12_8 . 9 0 0 0.478
tertdend12_8_2 . 9 0 0 0.478
tertdend12_9 . 9 0 0 0.419
tertdend12_9_2 . 9 0 0 0.419
tertdend12_10 . 9 0 0 0.359
tertdend12_10_2 . 9 0 0 0.359
tertdend12_11 . 9 0 0 0.3
tertdend12_11_2 . 9 0 0 0.3
     
tertdend13_1 secdend41 9 0 0 0.893
tertdend13_1_2 . 9 0 0 0.893
tertdend13_2 . 9 0 0 0.834
tertdend13_2_2 . 9 0 0 0.834
tertdend13_3 . 9 0 0 0.774
tertdend13_3_2 . 9 0 0 0.774
tertdend13_4 . 9 0 0 0.715
tertdend13_4_2 . 9 0 0 0.715
tertdend13_5 . 9 0 0 0.656
tertdend13_5_2 . 9 0 0 0.656
tertdend13_6 . 9 0 0 0.597
tertdend13_6_2 . 9 0 0 0.597
tertdend13_7 . 9 0 0 0.537
tertdend13_7_2 . 9 0 0 0.537
tertdend13_8 . 9 0 0 0.478
tertdend13_8_2 . 9 0 0 0.478
tertdend13_9 . 9 0 0 0.419
tertdend13_9_2 . 9 0 0 0.419
tertdend13_10 . 9 0 0 0.359
tertdend13_10_2 . 9 0 0 0.359
tertdend13_11 . 9 0 0 0.3
tertdend13_11_2 . 9 0 0 0.3
     
tertdend14_1 secdend41 9 0 0 0.893
tertdend14_1_2 . 9 0 0 0.893
tertdend14_2 . 9 0 0 0.834
tertdend14_2_2 . 9 0 0 0.834
tertdend14_3 . 9 0 0 0.774
tertdend14_3_2 . 9 0 0 0.774
tertdend14_4 . 9 0 0 0.715
tertdend14_4_2 . 9 0 0 0.715
tertdend14_5 . 9 0 0 0.656
tertdend14_5_2 . 9 0 0 0.656
tertdend14_6 . 9 0 0 0.597
tertdend14_6_2 . 9 0 0 0.597
tertdend14_7 . 9 0 0 0.537
tertdend14_7_2 . 9 0 0 0.537
tertdend14_8 . 9 0 0 0.478
tertdend14_8_2 . 9 0 0 0.478
tertdend14_9 . 9 0 0 0.419
tertdend14_9_2 . 9 0 0 0.419
tertdend14_10 . 9 0 0 0.359
tertdend14_10_2 . 9 0 0 0.359
tertdend14_11 . 9 0 0 0.3
tertdend14_11_2 . 9 0 0 0.3
     
tertdend15_1 secdend42 9 0 0 0.893
tertdend15_1_2 . 9 0 0 0.893
tertdend15_2 . 9 0 0 0.834
tertdend15_2_2 . 9 0 0 0.834
tertdend15_3 . 9 0 0 0.774
tertdend15_3_2 . 9 0 0 0.774
tertdend15_4 . 9 0 0 0.715
tertdend15_4_2 . 9 0 0 0.715
tertdend15_5 . 9 0 0 0.656
tertdend15_5_2 . 9 0 0 0.656
tertdend15_6 . 9 0 0 0.597
tertdend15_6_2 . 9 0 0 0.597
tertdend15_7 . 9 0 0 0.537
tertdend15_7_2 . 9 0 0 0.537
tertdend15_8 . 9 0 0 0.478
tertdend15_8_2 . 9 0 0 0.478
tertdend15_9 . 9 0 0 0.419
tertdend15_9_2 . 9 0 0 0.419
tertdend15_10 . 9 0 0 0.359
tertdend15_10_2 . 9 0 0 0.359
tertdend15_11 . 9 0 0 0.3
tertdend15_11_2 . 9 0 0 0.3
     
tertdend16_1 secdend42 9 0 0 0.893
tertdend16_1_2 . 9 0 0 0.893
tertdend16_2 . 9 0 0 0.834
tertdend16_2_2 . 9 0 0 0.834
tertdend16_3 . 9 0 0 0.774
tertdend16_3_2 . 9 0 0 0.774
tertdend16_4 . 9 0 0 0.715
tertdend16_4_2 . 9 0 0 0.715
tertdend16_5 . 9 0 0 0.656
tertdend16_5_2 . 9 0 0 0.656
tertdend16_6 . 9 0 0 0.597
tertdend16_6_2 . 9 0 0 0.597
tertdend16_7 . 9 0 0 0.537
tertdend16_7_2 . 9 0 0 0.537
tertdend16_8 . 9 0 0 0.478
tertdend16_8_2 . 9 0 0 0.478
tertdend16_9 . 9 0 0 0.419
tertdend16_9_2 . 9 0 0 0.419
tertdend16_10 . 9 0 0 0.359
tertdend16_10_2 . 9 0 0 0.359
tertdend16_11 . 9 0 0 0.3
tertdend16_11_2 . 9 0 0 0.3